Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

Background: Line of HIF-1α / Notch signaling regulate cell proliferation, apoptosis, and metabolism of the intervertebral disc (IVD) and is involved in disc degeneration. The nucleus pulposus (NP) is an important structure adjacent to the IVD. However, the role of HIF-1α / Notch signaling pathway in NP cells obtained from patients with different Modic changes (MC) is still unclear. The purpose of this study was to investigate the role of HIF-1α and components of the Notch pathway in NP obtained from patients with various MC.


Methods: A total of 85 NP tissue samples collected from patients who underwent diskectomy for the treatment of low back pain. NP network were divided into four groups based on the adjacent endplate degeneration, namely, MC I, II, III, and negative MC group. Expression of HIF-1α and Notch-related component is measured and compared.


Results: The expression of HIF-1α, Notch1 and Notch2 gradually increased in the first MC and MC II group than in the negative group MC. HIF-1α and Notch-related components are rarely detected in MC group III.
Conclusion: The expression of HIF-1α / Notch increased in cells of patients with NP MC MC I and II. HIF-1α and components related to the potential biomarkers Notch and HIF-1α / Notch signaling pathway may serve as a promising therapeutic target for disc degeneration in patients with MC.

Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain
Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

Targeting the Notch signaling pathway and TGF-β to prevent retinal fibrosis in vitro and in vivo

Rationale: Notch and transforming growth factor-β (TGFβ) two signaling pathways that control intracellular mechanisms of fibrosis in general, but if they play a major role in retinal fibrosis is less clear. Here we learn how these two signal pathways regulate cell Müller-dominated retinal fibrosis in vitro and in vivo. Methods: Human cells MIO-M1 Müller and TGFβ1 treated with Notch ligands, either alone or in combination. Western blot was conducted to study the changes protease γ-Secretase, Notch downstream effectors, endogenous TGFβ1, Smad3 phosphorylated (p-Smad3) and the extracellular matrix (ECM) proteins.

We also studied the effects RO4929097, a selective inhibitor of γ-Secretase, the ECM protein expression after ligand stimulation. Müller cell viability and cytotoxicity was studied by AlamarBlue to test the cytotoxicity of lactate. Finally, we studied the changes in Notch and TGFβ signaling and test the effect of an intravitreal injection of Notch pathway inhibitors RO4929097 on retinal fibrosis resulting from sodium iodate (NaIO3) -induced retinal injury in rats.

We also studied the security of RO4929097 intravitreal injection of normal mice. Results: Treatment of Muller cells with protease deregulated Notch ligand and Notch γ-Secretase downstream effector, with an increased expression of endogenous TGFβ1, TGFβ receptor and p-Smad3. TGFβ1 regulated expression of proteins associated with both signal paths in the same way. Notch ligands and TGFβ1 have an additive effect on ECM protein overexpression in Müller cells were inhibited by RO4929097. Notch and TGFβ ligand stimulates proliferation of Müller cells were inhibited by RO4929097 without damaging the cells. NaIO3-induced injury to the retina enabled both Notch and TGFβ signaling pathway in vivo intravitreal injection RO4929097 prevented gliosis Müller cells and inhibit excessive ECM proteins in this murine model.

Mouse Notch Signaling Primer Library

MNOT-I 1 set
EUR 657.6

LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles

RA900A-1 20 profiles
EUR 1020

PLATEMAX ULTRA CLEAR PERMANENT HEAT SEALING FILM FOR QPCR, 100/500

HS-100-QPCR 100/pk
EUR 381.6
Description: Sealing Products; Sealing films - Axygen

PLATEMAX ULTRA CLEAR PEELABLE HEAT SEALING FILM FOR QPCR. 100/500

HS-150-QPCR 100/pk
EUR 381.6
Description: Sealing Products; Sealing films - Axygen

Mouse LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles

RA930A-1 20 profiles
EUR 1020

Notch1/CSL Reporter Kit (Notch Signaling Pathway)

60509 500 rxns.
EUR 590
Description: The Notch Pathway Reporter kit is designed for monitoring the activity of Notch signaling pathway in the cultured cells. The kit contains the transfection-ready expression vector for Notch1 with the entire extracellular domain deleted (Notch1DE). Inside the cells, the Notch1DE can be cleaved by -secretase and active Notch1 NICD is released to nucleus. The kit also contains a CSL (CBF1/RBP-J) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized CSL responsive element upstream of a minimal promoter. The CSL (CBF1/RBP-J) reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutivelyexpressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway specific effects and background luciferase activity.

LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles

RA910A-1 20 profiles
EUR 1329.6

Notch Signaling Pathway Notch1/CSL Reporter - HEK293 Cell Line

60652 2 vials
EUR 2175
Description: The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the Notch1 E can be cleaved by γ-secretase. The active Notch1 NICD is released to nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway.

Transfection Collection™ : Notch1/CSL Transient Pack (Notch Signaling Pathway)

79285 500 rxns.
EUR 715
Description: The Notch1/CSL Transient Packis designed to provide the tools necessary for transiently transfecting and monitoring the activity of the Notch signaling pathway in HEK293 cultured cells. The kit contains transfection-ready vectors containing firefly luciferase as a Notch pathway-responsive reporter and constitutively expressing Renilla luciferase as a transfection control. It also includes the Dual Luciferase detection reagents to detect both luciferase activities and specialized medium for growing and assaying HEK293 cells._x000D_The key to the Notch1/CSL Transient Pack is the expression vector for NOTCH1 that has a deletion of the entire extracellular domain (Notch1DE). Inside the cells, the NOTCH1 DE can be cleaved by γ-secretase and active NOTCH1 NICD is released into the nucleus. The kit also contains CSL (CBF1/RBP-Jk) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains the firefly luciferase gene under the control of multimerized CSL responsive elements upstream of a minimal promoter. The CSL (CBF1/RBP-Jk) reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The pack also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway specific effects and background luciferase activity._x000D_Additionally, the pack includes cell culture medium (BPS Medium 1) that has been optimized for use with HEK293 cells*. BPS Medium 1 includes MEM medium, 10% fetal bovine serum, 1% non-essential amino acids, sodium pyruvate, and 1% Pen/Strep. Finally, the pack provides the Dual Luciferase (Firefly-Renilla) Assay System. These luciferase reagents provide highly sensitive, stable detection of firefly luciferase activity and Renilla luciferase activity. The dual luciferase reagents can be used directly in cells in growth medium, and can be detected with any luminometer; automated injectors are not required. _x000D_*Note: the kit may be used with other cell lines than HEK293, but an alternate cell culture medium may be required for optimal cell growth,

NOTCH Antibody

F53063-0.4ML 0.4 ml
EUR 379

QPCR Kit QPCR Mastermix DNA

MOL6354 EACH
EUR 231.42

Notch-1 (human) ELISA Kit

K4763-100 100 assays
EUR 970.8
Description: Sensitive, Colorimetric Assay

Notch 1 antibody

70R-31090 100 ug
EUR 392.4
Description: Rabbit polyclonal Notch 1 antibody

Notch 2 antibody

70R-31091 100 ug
EUR 392.4
Description: Rabbit polyclonal Notch 2 antibody

Notch 1 Antibody

48766-100ul 100ul
EUR 399.6

Notch 1 Antibody

48766-50ul 50ul
EUR 286.8

Notch 1 antibody

70R-12158 100 ug
EUR 483.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 antibody

10R-6539 50 ug
EUR 230.4
Description: Mouse monoclonal Notch 1 antibody

Notch 1 antibody

20R-1749 100 ug
EUR 807.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 Antibody

abx139789-01mg 0.1 mg
EUR 427.2

pGreenFire1-Notch (plasmid)

TR020PA-1 10 ug
EUR 943.2

pGreenFire1-Notch (virus)

TR020VA-1 >2 x 10^6 IFUs
EUR 943.2

anti-Notch 2

YF-PA24259 50 ul
EUR 400.8
Description: Mouse polyclonal to Notch 2

Notch 1 Antibody

3881-100 each
EUR 379.2

Notch 1 Antibody

3881-30T each
EUR 175.2

Human Cell Array I

17-601 1 pack
EUR 229.2
Description: Human cell lines (HEK293, A-431, A549, Hela S3, Hep G2 and MCF7)

Human Cell Array II

17-602 1 pack
EUR 229.2
Description: Human cell lines (HL-60, Jurkat, K-562, MOLT-4, Raji and THP-1)

Array Designer

AD6 1
EUR 5097.6

Nylon Array

MVSNGA110 10 Slides
EUR 271.2

Nylon Array

MVSNGA120 20 Slides
EUR 435.6

Human Statin Signaling Library

HSTAT-I 1 set
EUR 657.6

Human Notch Homolog 1 ELISA kit

E01N0594-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Notch Homolog 1 ELISA kit

E01N0594-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Notch Homolog 1 ELISA kit

E01N0594-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Notch Homolog 3 (NOTCH3) Protein

20-abx168112
  • EUR 794.40
  • EUR 326.40
  • EUR 2431.20
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Notch Homolog 4 (NOTCH4) Protein

20-abx166655
  • EUR 794.40
  • EUR 326.40
  • EUR 2448.00
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Notch Homolog 2 (NOTCH2) Protein

20-abx166840
  • EUR 811.20
  • EUR 343.20
  • EUR 2498.40
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

TranslationBlocker Human Notch-1 siRNA, 10nmol

QX37-10nmol 10nmol
EUR 452.4

TranslationBlocker Human Notch-1 siRNA, 2nmol

QX37-2nmol 2nmol
EUR 331.2

QPCR Kit RNA Human Influ

MOL6902 EACH
EUR 1220.94

QPCR Kit RNA Human Influ

MOL6906 EACH
EUR 1220.94

QPCR Kit RNA Human Influ

MOL6934 EACH
EUR 839.04

QPCR Kit DNA Human Bocav

MOL6938 EACH
EUR 772.92

QPCR Kit DNA Human HerpesviMmix

MOL6972 EACH
EUR 1069.32

QPCR Kit DNA Human HerpesviMmix

MOL6976 EACH
EUR 1069.32

QPCR Kit DNA Human Herpe

MOL6978 EACH
EUR 839.04

QPCR Kit DNA Human Herpe

MOL6982 EACH
EUR 804.84

QPCR Kit DNA Human HerpesviMmix

MOL6988 EACH
EUR 1069.32

QPCR Kit DNA Human HerpesviMmix

MOL6992 EACH
EUR 1069.32

QPCR Kit RNA Human Immun

MOL6994 EACH
EUR 864.12

QPCR Kit RNA Human Immun

MOL6998 EACH
EUR 864.12

QPCR Kit RNA Human Metap

MOL8024 EACH
EUR 839.04

QPCR Kit RNA Human Parai

MOL8032 EACH
EUR 820.8

QPCR Kit RNA Human Parai

MOL8036 EACH
EUR 820.8

QPCR Kit RNA Human Parai

MOL8040 EACH
EUR 820.8

QPCR Kit RNA Human Parai

MOL8044 EACH
EUR 840.18

QPCR Kit RNA Human Parai

MOL8048 EACH
EUR 788.88

QPCR Kit DNA Human Papil

MOL8052 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8056 EACH
EUR 839.04

QPCR Kit DNA Human Papil

MOL8060 EACH
EUR 839.04

QPCR Kit DNA Human Papil

MOL8064 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8068 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8072 EACH
EUR 839.04

QPCR Kit DNA Human Papil

MOL8076 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8080 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8084 EACH
EUR 772.92

QPCR Kit DNA Human Parvo

MOL8088 EACH
EUR 839.04

QPCR Kit DNA Human polyo

MOL8092 EACH
EUR 772.92

QPCR Kit DNA Human Polyo

MOL8096 EACH
EUR 772.92

QPCR Kit DNA Human Polyo

MOL8100 EACH
EUR 772.92

QPCR Kit DNA Human Polyo

MOL8104 EACH
EUR 772.92

QPCR Kit RNA Human Rhino

MOL8108 EACH
EUR 820.8

QPCR Kit RNA Human Rhino

MOL8112 EACH
EUR 839.04

QPCR Kit RNA Human Rhino

MOL8116 EACH
EUR 788.88

QPCR Kit RNA Human RhinoMmix

MOL8118 EACH
EUR 1010.04

QPCR Kit RNA Human Rhino

MOL8120 EACH
EUR 788.88

QPCR Kit RNA Human Rhino

MOL8124 EACH
EUR 788.88

QPCR Kit RNA Human Rhino

MOL8128 EACH
EUR 839.04

Notch-1 ELISA Kit| Mouse Neurogenic locus notch homolog protein

EF014010 96 Tests
EUR 826.8

Notch 1 Conjugated Antibody

C48766 100ul
EUR 476.4

Notch 1 homolog antibody

70R-NR026 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 1 homolog antibody

Notch 2 homolog antibody

70R-NR027 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 2 homolog antibody

Notch 3 homolog antibody

70R-NR028 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 3 homolog antibody

Notch 4 homolog antibody

70R-NR029 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 4 homolog antibody

Notch 3 antibody (PE)

61R-1343 100 ug
EUR 528
Description: Armenian Hamster monoclonal Notch3 antibody (PE)

Notch 4 antibody (PE)

61R-1344 25 ug
EUR 249.6
Description: Armenian Hamster monoclonal Notch4 antibody (PE)

Notch 1 antibody (PE)

61R-1347 100 ug
EUR 424.8
Description: Mouse monoclonal Notch 1 antibody (PE)

Notch 1 Blocking Peptide

33R-10562 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 20R-1749

Notch 1 Blocking Peptide

33R-10970 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 70R-12158

Notch 1 Antibody (APC)

abx139790-01mg 0.1 mg
EUR 510

Notch 1 Antibody (PE)

abx139791-01mg 0.1 mg
EUR 510

Notch 3 (NOTCH3) Antibody

20-abx214675
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Anti-NOTCH 2 Antibody

A00518 200uL
EUR 583.2
Description: Rabbit Polyclonal NOTCH 2 Antibody. Validated in IHC, WB and tested in Human.

Anti-NOTCH 1 Antibody

A00033 200uL
EUR 573.6
Description: Rabbit Polyclonal NOTCH 1 Antibody. Validated in IHC, WB and tested in Human.

Polyclonal Notch 1 Antibody

AMM06725G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Notch 1 . This antibody is tested and proven to work in the following applications:

Notch-1, mouse recombinant

7530-25 each
EUR 366

Notch-2, mouse recombinant

7531-25 each
EUR 366

Anti-NOTCH 2 Antibody

A1652-100 each
EUR 444

Anti-NOTCH 3 Antibody

A1653-100 each
EUR 444

Notch 1 Blocking Peptide

3881BP-50 each
EUR 183.6

Green qPCR SuperMix

20-abx098031
  • EUR 1245.60
  • EUR 526.80
  • EUR 760.80
  • 15 ml
  • 1 ml
  • 5 ml

Probe qPCR SuperMix

20-abx098040
  • EUR 1245.60
  • EUR 526.80
  • EUR 760.80
  • 15 ml
  • 1 ml
  • 5 ml

Universal qPCR Mixture

QPCR1000-UNIV 4X1.25ml
EUR 331.44

Multi-normal human tissues array

FDA999w3 each
EUR 266
Description: Multi-normal human tissues array, representing FDA guideline for antibody cross-reactivity testing, 32 types of human organs, 99 cores, each type taken from 3 different individuals (core size 1.5mm).

Multi-normal human tissue array

FDA999y3 each
EUR 355
Description: Multi-normal human tissue array,representing FDA guideline for antibody cross-reactivity testing, 99 cases/99 cores (core size 1.5mm).

Mouse Notch-1(Neurogenic locus notch homolog protein 1) ELISA Kit

EM1527 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Breast cancer tissue array and normal tissue array

BR726 each
EUR 306
Description: Breast cancer tissue array and normal tissue array, with TNM and grade, 24 cases/72 cores

Colon cancer test tissue array (4x (2x3) array)

T055a each
EUR 48
Description: Colon cancer test tissue array (4x (2x3) array), including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing T055

Colon cancer test tissue array (4x (2x3) array)

T055b each
EUR 48
Description: Colon cancer test tissue array (4x (2x3) array), including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing T055a

Kidney cancer test tissue array (4x (2x3)array)

T074a each
EUR 48
Description: Kidney cancer test tissue array (4x (2x3)array), including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing T074

Prostate cancer test tissue array (4x (2x3) array)

T196a each
EUR 66
Description: Prostate cancer test tissue array (4x (2x3) array), including pathology grade, Gleason grade, Gleason score, TNM and clinical stage, 6 cases/24 cores, replacing T196

Mouse Cell Array

17-701 1 pack
EUR 229.2
Description: Mouse cell lines (A-20, EL4, L1210, NIH/3T3, P815 and RAW 264.7)

Chordoma tissue array

BCS25011 each
EUR 270
Description: Chordoma tissue array, with P53 result, 12 cases/ 24 cores

Breast tissue array

BRN04a each
EUR 114
Description: Breast tissue array, 4 cases/4 cores (2.0mm), replacing BRN04

Ependymoma tissue array

GL151 each
EUR 238
Description: Ependymoma tissue array, including pathology grade, 15 cases/15 cores

Nephroblastoma tissue array

KD247 each
EUR 138
Description: Nephroblastoma tissue array, 24 cases/ 24 cores

Nephroblastoma tissue array

KD643 each
EUR 270
Description: Nephroblastoma tissue array, 64 cases/ 64 cores

Kidney tissue array

KD803b each
EUR 354
Description: Kidney tissue array, 80 cases/80n cores (core size 1.5mm), replacing KD803a

Lymphoma tissue array

LM482c each
EUR 270
Description: Lymphoma tissue array, containing 10 cases of myeloma and normal lymph node tissue, 48 cases/48 cores, replacing LM482b

Lymphoma tissue array

LY201 each
EUR 168
Description: Lymphoma tissue array, 20 cases/ 20 cores

Lymphoma tissue array

LY2087a each
EUR 546
Description: Lymphoma tissue array, 208 cases/208 cores, replacing LY2087

Lymphoma tissue array

LY302 each
EUR 168
Description: Lymphoma tissue array, 30 cases/ 30 cores (core size 2.0mm), replacing BS20011c. The previous Item# is BS20011d

Melanoma tissue array

ME483 each
EUR 270
Description: Melanoma tissue array, including TNM and clinical stage, 48 cases/48 cores, replaced by ME483a

Lymphoma tissue array

NHL803e each
EUR 348
Description: Lymphoma tissue array, 80 cases/80 cores (core size 1.5mm), replacing NHL803d

Oncocytoma tissue array

ON481 each
EUR 138
Description: Oncocytoma tissue array, 24 cases/48 cores

Osteosarcoma tissue array

OS804d each
EUR 354
Description: Osteosarcoma tissue array, including TNM and clinical stage, 40 cases/80 cores, replacing OS804c

Pancreatitis tissue array

PA691 each
EUR 306
Description: Pancreatitis tissue array, including Non-neoplastic pancreatitis,normal adjacent pancreatitis and cancer adjacent pancreatitis,68 cases/69 cores, replacing BBS14011.

Skin tissue array

SKN1001 each
EUR 354
Description: Skin tissue array, 50 cases/100 cores (core size 1.5mm),Recent Year Collection

Leiomyosarcoma tissue array

SO804b each
EUR 270
Description: Leiomyosarcoma tissue array, including TNM and clinical stage (AJCC 7th edition), 80 cases/80 cores (core size 1.5mm), replacing SO804

Lymphoma tissue array

T201b each
EUR 48
Description: Lymphoma tissue array, with normal lymph node tissue, 6 cases/24 cores, replacing T201a

Lymphoma tissue array

T201c each
EUR 48
Description: Lymphoma tissue array, with normal lymph node tissue, 6 cases/24 cores, replacing T201a

Human Notch Homolog 2 (NOTCH2) ELISA Kit

DLR-NOTCH2-Hu-48T 48T
EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Notch Homolog 2 (NOTCH2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Notch Homolog 2 (NOTCH2) ELISA Kit

DLR-NOTCH2-Hu-96T 96T
EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Notch Homolog 2 (NOTCH2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Notch Homolog 2 (NOTCH2) ELISA Kit

20-abx152540
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 3 (NOTCH3) CLIA Kit

20-abx495887
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 2 (NOTCH2) CLIA Kit

20-abx495888
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 4 (NOTCH4) CLIA Kit

20-abx495889
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 3 (NOTCH3) ELISA Kit

20-abx258645
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 4 (NOTCH4) ELISA Kit

20-abx258646
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Nori® Human Notch-1 ELISA Kit

GR106384 96-well
EUR 553.2

Notch Homolog 3 (NOTCH3) Polyclonal Antibody (Human)

4-PAL147Hu01
  • EUR 313.20
  • EUR 3280.80
  • EUR 811.20
  • EUR 396.00
  • EUR 264.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Notch Homolog 3 (NOTCH3)

Notch Homolog 2 (NOTCH2) Polyclonal Antibody (Human)

4-PAL148Hu01
  • EUR 314.40
  • EUR 3296.40
  • EUR 814.80
  • EUR 397.20
  • EUR 264.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Notch Homolog 2 (NOTCH2)

Human Notch Homolog 2 (NOTCH2) ELISA Kit

RD-NOTCH2-Hu-48Tests 48 Tests
EUR 675.6

Human Notch Homolog 2 (NOTCH2) ELISA Kit

RD-NOTCH2-Hu-96Tests 96 Tests
EUR 939.6

Human Notch Homolog 2 (NOTCH2) ELISA Kit

RDR-NOTCH2-Hu-48Tests 48 Tests
EUR 706.8

Human Notch Homolog 2 (NOTCH2) ELISA Kit

RDR-NOTCH2-Hu-96Tests 96 Tests
EUR 984

Human Notch Homolog 3 (NOTCH3) ELISA Kit

SEL147Hu-10x96wellstestplate 10x96-wells test plate
EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Notch Homolog 3 (NOTCH3) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Notch Homolog 3 (NOTCH3) ELISA Kit

SEL147Hu-1x48wellstestplate 1x48-wells test plate
EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Notch Homolog 3 (NOTCH3) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Notch Homolog 3 (NOTCH3) ELISA Kit

SEL147Hu-1x96wellstestplate 1x96-wells test plate
EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Notch Homolog 3 (NOTCH3) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Notch Homolog 3 (NOTCH3) ELISA Kit

SEL147Hu-5x96wellstestplate 5x96-wells test plate
EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Notch Homolog 3 (NOTCH3) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

We did not find any security issues until 17 days after intravitreal injection RO4929097. Conclusion: Inhibiting Notch signaling may be an effective way to prevent retinal fibrosis. This study is of clinical significance in developing treatments to prevent fibrosis in proliferative vitreoretinopathy, proliferative diabetic retinopathy and wet age-related macular degeneration.

Anthony

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Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

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