Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

Background: Line of HIF-1α / Notch signaling regulate cell proliferation, apoptosis, and metabolism of the intervertebral disc (IVD) and is involved in disc degeneration. The nucleus pulposus (NP) is an important structure adjacent to the IVD. However, the role of HIF-1α / Notch signaling pathway in NP cells obtained from patients with different Modic changes (MC) is still unclear. The purpose of this study was to investigate the role of HIF-1α and components of the Notch pathway in NP obtained from patients with various MC.


Methods: A total of 85 NP tissue samples collected from patients who underwent diskectomy for the treatment of low back pain. NP network were divided into four groups based on the adjacent endplate degeneration, namely, MC I, II, III, and negative MC group. Expression of HIF-1α and Notch-related component is measured and compared.


Results: The expression of HIF-1α, Notch1 and Notch2 gradually increased in the first MC and MC II group than in the negative group MC. HIF-1α and Notch-related components are rarely detected in MC group III.
Conclusion: The expression of HIF-1α / Notch increased in cells of patients with NP MC MC I and II. HIF-1α and components related to the potential biomarkers Notch and HIF-1α / Notch signaling pathway may serve as a promising therapeutic target for disc degeneration in patients with MC.

Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain
Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

Targeting the Notch signaling pathway and TGF-β to prevent retinal fibrosis in vitro and in vivo

Rationale: Notch and transforming growth factor-β (TGFβ) two signaling pathways that control intracellular mechanisms of fibrosis in general, but if they play a major role in retinal fibrosis is less clear. Here we learn how these two signal pathways regulate cell Müller-dominated retinal fibrosis in vitro and in vivo. Methods: Human cells MIO-M1 Müller and TGFβ1 treated with Notch ligands, either alone or in combination. Western blot was conducted to study the changes protease γ-Secretase, Notch downstream effectors, endogenous TGFβ1, Smad3 phosphorylated (p-Smad3) and the extracellular matrix (ECM) proteins.

We also studied the effects RO4929097, a selective inhibitor of γ-Secretase, the ECM protein expression after ligand stimulation. Müller cell viability and cytotoxicity was studied by AlamarBlue to test the cytotoxicity of lactate. Finally, we studied the changes in Notch and TGFβ signaling and test the effect of an intravitreal injection of Notch pathway inhibitors RO4929097 on retinal fibrosis resulting from sodium iodate (NaIO3) -induced retinal injury in rats.

We also studied the security of RO4929097 intravitreal injection of normal mice. Results: Treatment of Muller cells with protease deregulated Notch ligand and Notch γ-Secretase downstream effector, with an increased expression of endogenous TGFβ1, TGFβ receptor and p-Smad3. TGFβ1 regulated expression of proteins associated with both signal paths in the same way. Notch ligands and TGFβ1 have an additive effect on ECM protein overexpression in Müller cells were inhibited by RO4929097. Notch and TGFβ ligand stimulates proliferation of Müller cells were inhibited by RO4929097 without damaging the cells. NaIO3-induced injury to the retina enabled both Notch and TGFβ signaling pathway in vivo intravitreal injection RO4929097 prevented gliosis Müller cells and inhibit excessive ECM proteins in this murine model.

LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles

RA900A-1 20 profiles
EUR 1020

Mouse Notch Signaling Primer Library

MNOT-I 1 set
EUR 657.6

Mouse LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles

RA930A-1 20 profiles
EUR 1020

PLATEMAX ULTRA CLEAR PERMANENT HEAT SEALING FILM FOR QPCR, 100/500

HS-100-QPCR 100/pk
EUR 381.6
Description: Sealing Products; Sealing films - Axygen

PLATEMAX ULTRA CLEAR PEELABLE HEAT SEALING FILM FOR QPCR. 100/500

HS-150-QPCR 100/pk
EUR 381.6
Description: Sealing Products; Sealing films - Axygen

LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles

RA910A-1 20 profiles
EUR 1329.6

Array Designer

AD6 1
EUR 5097.6

Nylon Array

MVSNGA110 10 Slides
EUR 271.2

Nylon Array

MVSNGA120 20 Slides
EUR 435.6

Human Cell Array I

17-601 1 pack
EUR 229.2
Description: Human cell lines (HEK293, A-431, A549, Hela S3, Hep G2 and MCF7)

Human Cell Array II

17-602 1 pack
EUR 229.2
Description: Human cell lines (HL-60, Jurkat, K-562, MOLT-4, Raji and THP-1)

NOTCH Antibody

F53063-0.4ML 0.4 ml
EUR 379

QPCR Kit QPCR Mastermix DNA

MOL6354 EACH
EUR 231.42

Mouse Cell Array

17-701 1 pack
EUR 229.2
Description: Mouse cell lines (A-20, EL4, L1210, NIH/3T3, P815 and RAW 264.7)

Notch 1 antibody

70R-12158 100 ug
EUR 483.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 antibody

70R-31090 100 ug
EUR 392.4
Description: Rabbit polyclonal Notch 1 antibody

Notch 2 antibody

70R-31091 100 ug
EUR 392.4
Description: Rabbit polyclonal Notch 2 antibody

Notch 1 Antibody

3881-100
EUR 379.2

Notch 1 Antibody

3881-30T
EUR 175.2

Notch 1 Antibody

48766-100ul 100ul
EUR 399.6

Notch 1 Antibody

48766-50ul 50ul
EUR 286.8

Notch 1 antibody

10R-6539 50 ug
EUR 230.4
Description: Mouse monoclonal Notch 1 antibody

Notch 1 antibody

20R-1749 100 ug
EUR 807.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 Antibody

abx139789-01mg 0.1 mg
EUR 427.2

pGreenFire1-Notch (plasmid)

TR020PA-1 10 ug
EUR 943.2

pGreenFire1-Notch (virus)

TR020VA-1 >2 x 10^6 IFUs
EUR 943.2

anti-Notch 2

YF-PA24259 50 ul
EUR 400.8
Description: Mouse polyclonal to Notch 2

Notch-1 (human) ELISA Kit

K4763-100 100 assays
EUR 970.8
Description: Sensitive, Colorimetric Assay

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)

T8234708-2 2 slides
EUR 368.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)

T8234708-5 5 slides
EUR 694.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Amino Particle Array Kit

APAK-3567-7K 7X1 mL
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Description: Amino Particle Array KitGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Fluorescent Particle Array Kit

FPAK-4058--10K 10 mL
EUR 675.6
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Blue Particle Array Kit

PAK-3567-7K 7X1 mL
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Blue Particle Array Kit

PAK-4067-8K 8X1 mL
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Blue Particle Array Kit

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Blue Particle Array Kit

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Blue Particle Array Kit

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FDA Standard Tissue Array

T8234701-1 1 slides
EUR 256.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Tissue Array

T8234701-5 5 slides
EUR 784.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

CA125 antibody array kit

VArk-Lsx008 1 mg
EUR 796.8
Description: CA125 can be used as a tumor marker to identify the type of tumor and check if the treatment is working.

Ferritin antibody array kit

VArk-Lsx009 1 mg
EUR 502.8
Description: Used for detection of Ferritin

Microalbuminuria antibody array kit

VArk-Lsx010 1 mg
EUR 502.8
Description: Used to detect early signs of kidney damage

Human Notch Homolog 3 (NOTCH3) Protein

20-abx168112
  • EUR 794.40
  • EUR 326.40
  • EUR 2431.20
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Notch Homolog 4 (NOTCH4) Protein

20-abx166655
  • EUR 794.40
  • EUR 326.40
  • EUR 2448.00
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Notch Homolog 2 (NOTCH2) Protein

20-abx166840
  • EUR 811.20
  • EUR 343.20
  • EUR 2498.40
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Notch Homolog 1 ELISA kit

E01N0594-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Notch Homolog 1 ELISA kit

E01N0594-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Notch Homolog 1 ELISA kit

E01N0594-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

TranslationBlocker Human Notch-1 siRNA, 10nmol

QX37-10nmol 10nmol
EUR 452.4

TranslationBlocker Human Notch-1 siRNA, 2nmol

QX37-2nmol 2nmol
EUR 331.2

Notch-1 ELISA Kit| Mouse Neurogenic locus notch homolog protein

EF014010 96 Tests
EUR 826.8

Notch 3 antibody (PE)

61R-1343 100 ug
EUR 528
Description: Armenian Hamster monoclonal Notch3 antibody (PE)

Notch 4 antibody (PE)

61R-1344 25 ug
EUR 249.6
Description: Armenian Hamster monoclonal Notch4 antibody (PE)

Notch 1 antibody (PE)

61R-1347 100 ug
EUR 424.8
Description: Mouse monoclonal Notch 1 antibody (PE)

Anti-NOTCH 2 Antibody

A00518 200uL
EUR 583.2
Description: Rabbit Polyclonal NOTCH 2 Antibody. Validated in IHC, WB and tested in Human.

Notch 1 Blocking Peptide

3881BP-50
EUR 183.6

Notch 1 Blocking Peptide

33R-10970 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 70R-12158

Notch 1 Blocking Peptide

33R-10562 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 20R-1749

Notch 1 Antibody (APC)

abx139790-01mg 0.1 mg
EUR 510

Notch 1 Antibody (PE)

abx139791-01mg 0.1 mg
EUR 510

Anti-NOTCH 3 Antibody

A1653-100
EUR 444

Notch 3 (NOTCH3) Antibody

20-abx214675
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Notch 1 homolog antibody

70R-NR026 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 1 homolog antibody

Notch 2 homolog antibody

70R-NR027 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 2 homolog antibody

Notch 3 homolog antibody

70R-NR028 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 3 homolog antibody

Notch 4 homolog antibody

70R-NR029 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 4 homolog antibody

Notch-1, mouse recombinant

7530-25
EUR 366

Notch-2, mouse recombinant

7531-25
EUR 366

Anti-NOTCH 1 Antibody

A00033 200uL
EUR 573.6
Description: Rabbit Polyclonal NOTCH 1 Antibody. Validated in IHC, WB and tested in Human.

Polyclonal Notch 1 Antibody

AMM06725G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Notch 1 . This antibody is tested and proven to work in the following applications:

Notch 1 Conjugated Antibody

C48766 100ul
EUR 476.4

QPCR Kit RNA Human Influ

MOL6902 EACH
EUR 1220.94

QPCR Kit RNA Human Influ

MOL6906 EACH
EUR 1220.94

QPCR Kit RNA Human Influ

MOL6934 EACH
EUR 839.04

QPCR Kit DNA Human Bocav

MOL6938 EACH
EUR 772.92

QPCR Kit DNA Human HerpesviMmix

MOL6972 EACH
EUR 1069.32

QPCR Kit DNA Human HerpesviMmix

MOL6976 EACH
EUR 1069.32

QPCR Kit DNA Human Herpe

MOL6978 EACH
EUR 839.04

QPCR Kit DNA Human Herpe

MOL6982 EACH
EUR 804.84

QPCR Kit DNA Human HerpesviMmix

MOL6988 EACH
EUR 1069.32

QPCR Kit DNA Human HerpesviMmix

MOL6992 EACH
EUR 1069.32

QPCR Kit RNA Human Immun

MOL6994 EACH
EUR 864.12

QPCR Kit RNA Human Immun

MOL6998 EACH
EUR 864.12

QPCR Kit RNA Human Metap

MOL8024 EACH
EUR 839.04

QPCR Kit RNA Human Parai

MOL8032 EACH
EUR 820.8

QPCR Kit RNA Human Parai

MOL8036 EACH
EUR 820.8

QPCR Kit RNA Human Parai

MOL8040 EACH
EUR 820.8

QPCR Kit RNA Human Parai

MOL8044 EACH
EUR 840.18

QPCR Kit RNA Human Parai

MOL8048 EACH
EUR 788.88

QPCR Kit DNA Human Papil

MOL8052 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8056 EACH
EUR 839.04

QPCR Kit DNA Human Papil

MOL8060 EACH
EUR 839.04

QPCR Kit DNA Human Papil

MOL8064 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8068 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8072 EACH
EUR 839.04

QPCR Kit DNA Human Papil

MOL8076 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8080 EACH
EUR 772.92

QPCR Kit DNA Human Papil

MOL8084 EACH
EUR 772.92

QPCR Kit DNA Human Parvo

MOL8088 EACH
EUR 839.04

QPCR Kit DNA Human polyo

MOL8092 EACH
EUR 772.92

QPCR Kit DNA Human Polyo

MOL8096 EACH
EUR 772.92

QPCR Kit DNA Human Polyo

MOL8100 EACH
EUR 772.92

QPCR Kit DNA Human Polyo

MOL8104 EACH
EUR 772.92

QPCR Kit RNA Human Rhino

MOL8108 EACH
EUR 820.8

QPCR Kit RNA Human Rhino

MOL8112 EACH
EUR 839.04

QPCR Kit RNA Human Rhino

MOL8116 EACH
EUR 788.88

QPCR Kit RNA Human RhinoMmix

MOL8118 EACH
EUR 1010.04

QPCR Kit RNA Human Rhino

MOL8120 EACH
EUR 788.88

QPCR Kit RNA Human Rhino

MOL8124 EACH
EUR 788.88

QPCR Kit RNA Human Rhino

MOL8128 EACH
EUR 839.04

Human Statin Signaling Library

HSTAT-I 1 set
EUR 657.6

Green qPCR SuperMix

20-abx098031
  • EUR 1245.60
  • EUR 526.80
  • EUR 760.80
  • 15 ml
  • 1 ml
  • 5 ml

Probe qPCR SuperMix

20-abx098040
  • EUR 1245.60
  • EUR 526.80
  • EUR 760.80
  • 15 ml
  • 1 ml
  • 5 ml

Universal qPCR Mixture

QPCR1000-UNIV 4X1.25ml
EUR 331.44

Mouse Notch-1(Neurogenic locus notch homolog protein 1) ELISA Kit

EM1527 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Carboxyl Blue Particle Array Kit

CPAK-10067--13K 13X1 mL
EUR 1138.8
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-3067--7K 7X1 mL
EUR 675.6
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-3567--4K 4X1 mL
EUR 420
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-3567--7K 7X1 mL
EUR 675.6
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-4067--8K 8X1 mL
EUR 675.6
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-5067--10K 10 mL
EUR 1126.8
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Carboxyl Blue Particle Array Kit

CPAK-5067--5A 5X1 mL
EUR 675.6
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Carboxyl Blue Particle Array Kit

CPAK-5067--5B 5X1 mL
EUR 675.6
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Carboxyl Yellow Particle Array Kit

CPAK-7052--3K 3X1 mL
EUR 486
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Carboxyl Yellow Particle Array Kit

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EUR 834
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Carboxyl Blue Particle Array Kit

CPAK-7067--9K 9X1 mL
EUR 1126.8
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Exo-Check Exosome Antibody Array

EXORAY200A-4 4 arrays
EUR 648

Exo-Check Exosome Antibody Array

EXORAY210A-8 8 arrays
EUR 1176

Glutathione Blue Particle Array Kit

GSHPAK--5067-4K 4X1 mL
EUR 949.2
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Streptavidin Blue Array Particle Kit

SVPAK-5067--10K 10 mL
EUR 1192.8
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Streptavidin Blue Array Particle Kit

SVPAK-5067--5A 5X1 mL
EUR 705.6
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Streptavidin Blue Array Particle Kit

SVPAK-5067--5B 5X1 mL
EUR 705.6
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UV Carboxyl Particle Array Kit

UVCPAK--5042-14K 14X1 mL
EUR 1533.6
Description: UltraRainbow Fluorescent Particlesare calibration particles that help you to determine if a flow cytometer is properly aligned and has a clean flow cell with no fluidic blockage. Using SPHERO? Alignment Particles, the coefficients of variation (CVs), peak channels, and histogram distributions can be measured to determine the alignment and functionality of the flow cytometer.

HIV-P24 antigen array kit

VArk-Lsx001 unit Ask for price
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood.

HCV core antigen array kit

VArk-Lsx002 unit Ask for price
Description: Measure the HCV core protein.

Procalcitonin (PCT) Antigen array kit

VArk-Lsx004 1 mg
EUR 973.2
Description: Used as an early and highly accurate biomarker for sepsis and infection.

NT-pro BNP array kit

VArk-Lsx007 1 mg
EUR 1786.8
Description: To help detect, diagnose, and evaluate the severity of congestive heart failure (CHF)

Exo-Check Exosome Antibody Array

322-EXO-FBS-50A-1 100 µg
EUR 469.2

Human Notch Homolog 2 (NOTCH2) ELISA Kit

20-abx152540
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 3 (NOTCH3) CLIA Kit

20-abx495887
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 2 (NOTCH2) CLIA Kit

20-abx495888
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 4 (NOTCH4) CLIA Kit

20-abx495889
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 3 (NOTCH3) ELISA Kit

20-abx258645
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 4 (NOTCH4) ELISA Kit

20-abx258646
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Notch Homolog 2 (NOTCH2) ELISA Kit

DLR-NOTCH2-Hu-48T 48T
EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Notch Homolog 2 (NOTCH2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Notch Homolog 2 (NOTCH2) ELISA Kit

DLR-NOTCH2-Hu-96T 96T
EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Notch Homolog 2 (NOTCH2) in samples from tissue homogenates, cell lysates or other biological fluids.

Nori® Human Notch-1 ELISA Kit

GR106384 96-well
EUR 553.2

Notch Homolog 3 (NOTCH3) Polyclonal Antibody (Human)

4-PAL147Hu01
  • EUR 313.20
  • EUR 3280.80
  • EUR 811.20
  • EUR 396.00
  • EUR 264.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Notch Homolog 3 (NOTCH3)

Notch Homolog 2 (NOTCH2) Polyclonal Antibody (Human)

4-PAL148Hu01
  • EUR 314.40
  • EUR 3296.40
  • EUR 814.80
  • EUR 397.20
  • EUR 264.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Notch Homolog 2 (NOTCH2)

We did not find any security issues until 17 days after intravitreal injection RO4929097. Conclusion: Inhibiting Notch signaling may be an effective way to prevent retinal fibrosis. This study is of clinical significance in developing treatments to prevent fibrosis in proliferative vitreoretinopathy, proliferative diabetic retinopathy and wet age-related macular degeneration.

Anthony

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Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

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