Background: Line of HIF-1α / Notch signaling regulate cell proliferation, apoptosis, and metabolism of the intervertebral disc (IVD) and is involved in disc degeneration. The nucleus pulposus (NP) is an important structure adjacent to the IVD. However, the role of HIF-1α / Notch signaling pathway in NP cells obtained from patients with different Modic changes (MC) is still unclear. The purpose of this study was to investigate the role of HIF-1α and components of the Notch pathway in NP obtained from patients with various MC.

Methods: A total of 85 NP tissue samples collected from patients who underwent diskectomy for the treatment of low back pain. NP network were divided into four groups based on the adjacent endplate degeneration, namely, MC I, II, III, and negative MC group. Expression of HIF-1α and Notch-related component is measured and compared.

Results: The expression of HIF-1α, Notch1 and Notch2 gradually increased in the first MC and MC II group than in the negative group MC. HIF-1α and Notch-related components are rarely detected in MC group III.
Conclusion: The expression of HIF-1α / Notch increased in cells of patients with NP MC MC I and II. HIF-1α and components related to the potential biomarkers Notch and HIF-1α / Notch signaling pathway may serve as a promising therapeutic target for disc degeneration in patients with MC.

Targeting the Notch signaling pathway and TGF-β to prevent retinal fibrosis in vitro and in vivo

Rationale: Notch and transforming growth factor-β (TGFβ) two signaling pathways that control intracellular mechanisms of fibrosis in general, but if they play a major role in retinal fibrosis is less clear. Here we learn how these two signal pathways regulate cell Müller-dominated retinal fibrosis in vitro and in vivo. Methods: Human cells MIO-M1 Müller and TGFβ1 treated with Notch ligands, either alone or in combination. Western blot was conducted to study the changes protease γ-Secretase, Notch downstream effectors, endogenous TGFβ1, Smad3 phosphorylated (p-Smad3) and the extracellular matrix (ECM) proteins.

We also studied the effects RO4929097, a selective inhibitor of γ-Secretase, the ECM protein expression after ligand stimulation. Müller cell viability and cytotoxicity was studied by AlamarBlue to test the cytotoxicity of lactate. Finally, we studied the changes in Notch and TGFβ signaling and test the effect of an intravitreal injection of Notch pathway inhibitors RO4929097 on retinal fibrosis resulting from sodium iodate (NaIO3) -induced retinal injury in rats.

We also studied the security of RO4929097 intravitreal injection of normal mice. Results: Treatment of Muller cells with protease deregulated Notch ligand and Notch γ-Secretase downstream effector, with an increased expression of endogenous TGFβ1, TGFβ receptor and p-Smad3. TGFβ1 regulated expression of proteins associated with both signal paths in the same way. Notch ligands and TGFβ1 have an additive effect on ECM protein overexpression in Müller cells were inhibited by RO4929097. Notch and TGFβ ligand stimulates proliferation of Müller cells were inhibited by RO4929097 without damaging the cells. NaIO3-induced injury to the retina enabled both Notch and TGFβ signaling pathway in vivo intravitreal injection RO4929097 prevented gliosis Müller cells and inhibit excessive ECM proteins in this murine model.

LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles
RA900A-1	SBI	20 profiles	EUR 1020

Mouse Notch Signaling Primer Library
MNOT-I	Real Time Primers	1 set	EUR 657.6

Mouse LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles
RA930A-1	SBI	20 profiles	EUR 1020

PLATEMAX ULTRA CLEAR PERMANENT HEAT SEALING FILM FOR QPCR, 100/500
HS-100-QPCR	CORNING	100/pk	EUR 381.6
Description: Sealing Products; Sealing films - Axygen

PLATEMAX ULTRA CLEAR PEELABLE HEAT SEALING FILM FOR QPCR. 100/500
HS-150-QPCR	CORNING	100/pk	EUR 381.6
Description: Sealing Products; Sealing films - Axygen

LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles
RA910A-1	SBI	20 profiles	EUR 1329.6

Array Designer
AD6	Premier Biosoft	1	EUR 5097.6

Nylon Array
MVSNGA110	Neuromics	10 Slides	EUR 271.2

Nylon Array
MVSNGA120	Neuromics	20 Slides	EUR 435.6

Human Cell Array I
17-601	ProSci	1 pack	EUR 229.2
Description: Human cell lines (HEK293, A-431, A549, Hela S3, Hep G2 and MCF7)

Human Cell Array II
17-602	ProSci	1 pack	EUR 229.2
Description: Human cell lines (HL-60, Jurkat, K-562, MOLT-4, Raji and THP-1)

NOTCH Antibody
F53063-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

QPCR Kit QPCR Mastermix DNA
MOL6354	Scientific Laboratory Supplies	EACH	EUR 231.42

Mouse Cell Array
17-701	ProSci	1 pack	EUR 229.2
Description: Mouse cell lines (A-20, EL4, L1210, NIH/3T3, P815 and RAW 264.7)

Notch 1 antibody
70R-12158	Fitzgerald	100 ug	EUR 483.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 antibody
70R-31090	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal Notch 1 antibody

Notch 2 antibody
70R-31091	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal Notch 2 antibody

Notch 1 Antibody
3881-100	Biovision		EUR 379.2

Notch 1 Antibody
3881-30T	Biovision		EUR 175.2

Notch 1 Antibody
48766-100ul	SAB	100ul	EUR 399.6

Notch 1 Antibody
48766-50ul	SAB	50ul	EUR 286.8

Notch 1 antibody
10R-6539	Fitzgerald	50 ug	EUR 230.4
Description: Mouse monoclonal Notch 1 antibody

Notch 1 antibody
20R-1749	Fitzgerald	100 ug	EUR 807.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 Antibody
abx139789-01mg	Abbexa	0.1 mg	EUR 427.2

pGreenFire1-Notch (plasmid)
TR020PA-1	SBI	10 ug	EUR 943.2

pGreenFire1-Notch (virus)
TR020VA-1	SBI	>2 x 10^6 IFUs	EUR 943.2

anti-Notch 2
YF-PA24259	Abfrontier	50 ul	EUR 400.8
Description: Mouse polyclonal to Notch 2

Notch-1 (human) ELISA Kit
K4763-100	Biovision	100 assays	EUR 970.8
Description: Sensitive, Colorimetric Assay

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)
T8234708-2	Biochain	2 slides	EUR 368.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)
T8234708-5	Biochain	5 slides	EUR 694.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Amino Particle Array Kit
APAK-3567-7K	Spherotech	7X1 mL	EUR 669.6
Description: Amino Particle Array KitGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Fluorescent Particle Array Kit
FPAK-4058--10K	Spherotech	10 mL	EUR 675.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Blue Particle Array Kit
PAK-3567-7K	Spherotech	7X1 mL	EUR 675.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Blue Particle Array Kit
PAK-4067-8K	Spherotech	8X1 mL	EUR 675.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Blue Particle Array Kit
PAK-5067-10K	Spherotech	10X1 mL	EUR 1126.8
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Blue Particle Array Kit
PAK-5067-5A	Spherotech	5X1 mL	EUR 675.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Blue Particle Array Kit
PAK-5067-5B	Spherotech	5X1 mL	EUR 675.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Blue Particle Array Kit
PAK-7067-9K	Spherotech	9X1 mL	EUR 1126.8
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

FDA Standard Tissue Array
T8234701-1	Biochain	1 slides	EUR 256.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Tissue Array
T8234701-5	Biochain	5 slides	EUR 784.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

CA125 antibody array kit
VArk-Lsx008	Creative Biolabs	1 mg	EUR 796.8
Description: CA125 can be used as a tumor marker to identify the type of tumor and check if the treatment is working.

Ferritin antibody array kit
VArk-Lsx009	Creative Biolabs	1 mg	EUR 502.8
Description: Used for detection of Ferritin

Microalbuminuria antibody array kit
VArk-Lsx010	Creative Biolabs	1 mg	EUR 502.8
Description: Used to detect early signs of kidney damage

Human Notch Homolog 3 (NOTCH3) Protein
20-abx168112	Abbexa	EUR 794.40 EUR 326.40 EUR 2431.20 EUR 944.40 EUR 577.20	100 ug 10 ug 1 mg 200 ug 50 ug

Human Notch Homolog 4 (NOTCH4) Protein
20-abx166655	Abbexa	EUR 794.40 EUR 326.40 EUR 2448.00 EUR 944.40 EUR 577.20	100 ug 10 ug 1 mg 200 ug 50 ug

Human Notch Homolog 2 (NOTCH2) Protein
20-abx166840	Abbexa	EUR 811.20 EUR 343.20 EUR 2498.40 EUR 961.20 EUR 577.20	100 ug 10 ug 1 mg 200 ug 50 ug

Human Notch Homolog 1 ELISA kit
E01N0594-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Notch Homolog 1 ELISA kit
E01N0594-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Notch Homolog 1 ELISA kit
E01N0594-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

TranslationBlocker Human Notch-1 siRNA, 10nmol
QX37-10nmol	EnQuireBio	10nmol	EUR 452.4

TranslationBlocker Human Notch-1 siRNA, 2nmol
QX37-2nmol	EnQuireBio	2nmol	EUR 331.2

Notch-1 ELISA Kit| Mouse Neurogenic locus notch homolog protein
EF014010	Lifescience Market	96 Tests	EUR 826.8

Notch 3 antibody (PE)
61R-1343	Fitzgerald	100 ug	EUR 528
Description: Armenian Hamster monoclonal Notch3 antibody (PE)

Notch 4 antibody (PE)
61R-1344	Fitzgerald	25 ug	EUR 249.6
Description: Armenian Hamster monoclonal Notch4 antibody (PE)

Notch 1 antibody (PE)
61R-1347	Fitzgerald	100 ug	EUR 424.8
Description: Mouse monoclonal Notch 1 antibody (PE)

Anti-NOTCH 2 Antibody
A00518	BosterBio	200uL	EUR 583.2
Description: Rabbit Polyclonal NOTCH 2 Antibody. Validated in IHC, WB and tested in Human.

Notch 1 Blocking Peptide
3881BP-50	Biovision		EUR 183.6

Notch 1 Blocking Peptide
33R-10970	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 70R-12158

Notch 1 Blocking Peptide
33R-10562	Fitzgerald	50 ug	EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 20R-1749

Notch 1 Antibody (APC)
abx139790-01mg	Abbexa	0.1 mg	EUR 510

Notch 1 Antibody (PE)
abx139791-01mg	Abbexa	0.1 mg	EUR 510

Anti-NOTCH 3 Antibody
A1653-100	Biovision		EUR 444

Notch 3 (NOTCH3) Antibody
20-abx214675	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Notch 1 homolog antibody
70R-NR026	Fitzgerald	100 ug	EUR 360
Description: Affinity purified Rabbit polyclonal Notch 1 homolog antibody

Notch 2 homolog antibody
70R-NR027	Fitzgerald	100 ug	EUR 360
Description: Affinity purified Rabbit polyclonal Notch 2 homolog antibody

Notch 3 homolog antibody
70R-NR028	Fitzgerald	100 ug	EUR 360
Description: Affinity purified Rabbit polyclonal Notch 3 homolog antibody

Notch 4 homolog antibody
70R-NR029	Fitzgerald	100 ug	EUR 360
Description: Affinity purified Rabbit polyclonal Notch 4 homolog antibody

Notch-1, mouse recombinant
7530-25	Biovision		EUR 366

Notch-2, mouse recombinant
7531-25	Biovision		EUR 366

Anti-NOTCH 1 Antibody
A00033	BosterBio	200uL	EUR 573.6
Description: Rabbit Polyclonal NOTCH 1 Antibody. Validated in IHC, WB and tested in Human.

Polyclonal Notch 1 Antibody
AMM06725G	Leading Biology	0.1mg	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Notch 1 . This antibody is tested and proven to work in the following applications:

Notch 1 Conjugated Antibody
C48766	SAB	100ul	EUR 476.4

QPCR Kit RNA Human Influ
MOL6902	Scientific Laboratory Supplies	EACH	EUR 1220.94

QPCR Kit RNA Human Influ
MOL6906	Scientific Laboratory Supplies	EACH	EUR 1220.94

QPCR Kit RNA Human Influ
MOL6934	Scientific Laboratory Supplies	EACH	EUR 839.04

QPCR Kit DNA Human Bocav
MOL6938	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human HerpesviMmix
MOL6972	Scientific Laboratory Supplies	EACH	EUR 1069.32

QPCR Kit DNA Human HerpesviMmix
MOL6976	Scientific Laboratory Supplies	EACH	EUR 1069.32

QPCR Kit DNA Human Herpe
MOL6978	Scientific Laboratory Supplies	EACH	EUR 839.04

QPCR Kit DNA Human Herpe
MOL6982	Scientific Laboratory Supplies	EACH	EUR 804.84

QPCR Kit DNA Human HerpesviMmix
MOL6988	Scientific Laboratory Supplies	EACH	EUR 1069.32

QPCR Kit DNA Human HerpesviMmix
MOL6992	Scientific Laboratory Supplies	EACH	EUR 1069.32

QPCR Kit RNA Human Immun
MOL6994	Scientific Laboratory Supplies	EACH	EUR 864.12

QPCR Kit RNA Human Immun
MOL6998	Scientific Laboratory Supplies	EACH	EUR 864.12

QPCR Kit RNA Human Metap
MOL8024	Scientific Laboratory Supplies	EACH	EUR 839.04

QPCR Kit RNA Human Parai
MOL8032	Scientific Laboratory Supplies	EACH	EUR 820.8

QPCR Kit RNA Human Parai
MOL8036	Scientific Laboratory Supplies	EACH	EUR 820.8

QPCR Kit RNA Human Parai
MOL8040	Scientific Laboratory Supplies	EACH	EUR 820.8

QPCR Kit RNA Human Parai
MOL8044	Scientific Laboratory Supplies	EACH	EUR 840.18

QPCR Kit RNA Human Parai
MOL8048	Scientific Laboratory Supplies	EACH	EUR 788.88

QPCR Kit DNA Human Papil
MOL8052	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human Papil
MOL8056	Scientific Laboratory Supplies	EACH	EUR 839.04

QPCR Kit DNA Human Papil
MOL8060	Scientific Laboratory Supplies	EACH	EUR 839.04

QPCR Kit DNA Human Papil
MOL8064	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human Papil
MOL8068	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human Papil
MOL8072	Scientific Laboratory Supplies	EACH	EUR 839.04

QPCR Kit DNA Human Papil
MOL8076	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human Papil
MOL8080	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human Papil
MOL8084	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human Parvo
MOL8088	Scientific Laboratory Supplies	EACH	EUR 839.04

QPCR Kit DNA Human polyo
MOL8092	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human Polyo
MOL8096	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human Polyo
MOL8100	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit DNA Human Polyo
MOL8104	Scientific Laboratory Supplies	EACH	EUR 772.92

QPCR Kit RNA Human Rhino
MOL8108	Scientific Laboratory Supplies	EACH	EUR 820.8

QPCR Kit RNA Human Rhino
MOL8112	Scientific Laboratory Supplies	EACH	EUR 839.04

QPCR Kit RNA Human Rhino
MOL8116	Scientific Laboratory Supplies	EACH	EUR 788.88

QPCR Kit RNA Human RhinoMmix
MOL8118	Scientific Laboratory Supplies	EACH	EUR 1010.04

QPCR Kit RNA Human Rhino
MOL8120	Scientific Laboratory Supplies	EACH	EUR 788.88

QPCR Kit RNA Human Rhino
MOL8124	Scientific Laboratory Supplies	EACH	EUR 788.88

QPCR Kit RNA Human Rhino
MOL8128	Scientific Laboratory Supplies	EACH	EUR 839.04

Human Statin Signaling Library
HSTAT-I	Real Time Primers	1 set	EUR 657.6

Green qPCR SuperMix
20-abx098031	Abbexa	EUR 1245.60 EUR 526.80 EUR 760.80	15 ml 1 ml 5 ml

Probe qPCR SuperMix
20-abx098040	Abbexa	EUR 1245.60 EUR 526.80 EUR 760.80	15 ml 1 ml 5 ml

Universal qPCR Mixture
QPCR1000-UNIV	Bio Basic	4X1.25ml	EUR 331.44

Mouse Notch-1(Neurogenic locus notch homolog protein 1) ELISA Kit
EM1527	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Carboxyl Blue Particle Array Kit
CPAK-10067--13K	Spherotech	13X1 mL	EUR 1138.8
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit
CPAK-3067--7K	Spherotech	7X1 mL	EUR 675.6
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit
CPAK-3567--4K	Spherotech	4X1 mL	EUR 420
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit
CPAK-3567--7K	Spherotech	7X1 mL	EUR 675.6
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit
CPAK-4067--8K	Spherotech	8X1 mL	EUR 675.6
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit
CPAK-5067--10K	Spherotech	10 mL	EUR 1126.8
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Blue Particle Array Kit
CPAK-5067--5A	Spherotech	5X1 mL	EUR 675.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Blue Particle Array Kit
CPAK-5067--5B	Spherotech	5X1 mL	EUR 675.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Yellow Particle Array Kit
CPAK-7052--3K	Spherotech	3X1 mL	EUR 486
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Yellow Particle Array Kit
CPAK-7052--6K	Spherotech	6x1 mL	EUR 834
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Blue Particle Array Kit
CPAK-7067--9K	Spherotech	9X1 mL	EUR 1126.8
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Exo-Check Exosome Antibody Array
EXORAY200A-4	SBI	4 arrays	EUR 648

Exo-Check Exosome Antibody Array
EXORAY210A-8	SBI	8 arrays	EUR 1176

Glutathione Blue Particle Array Kit
GSHPAK--5067-4K	Spherotech	4X1 mL	EUR 949.2
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Streptavidin Blue Array Particle Kit
SVPAK-5067--10K	Spherotech	10 mL	EUR 1192.8
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Streptavidin Blue Array Particle Kit
SVPAK-5067--5A	Spherotech	5X1 mL	EUR 705.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Streptavidin Blue Array Particle Kit
SVPAK-5067--5B	Spherotech	5X1 mL	EUR 705.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

UV Carboxyl Particle Array Kit
UVCPAK--5042-14K	Spherotech	14X1 mL	EUR 1533.6
Description: UltraRainbow Fluorescent Particlesare calibration particles that help you to determine if a flow cytometer is properly aligned and has a clean flow cell with no fluidic blockage. Using SPHERO? Alignment Particles, the coefficients of variation (CVs), peak channels, and histogram distributions can be measured to determine the alignment and functionality of the flow cytometer.

HIV-P24 antigen array kit
VArk-Lsx001	Creative Biolabs	unit	Ask for price
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood.

HCV core antigen array kit
VArk-Lsx002	Creative Biolabs	unit	Ask for price
Description: Measure the HCV core protein.

Procalcitonin (PCT) Antigen array kit
VArk-Lsx004	Creative Biolabs	1 mg	EUR 973.2
Description: Used as an early and highly accurate biomarker for sepsis and infection.

NT-pro BNP array kit
VArk-Lsx007	Creative Biolabs	1 mg	EUR 1786.8
Description: To help detect, diagnose, and evaluate the severity of congestive heart failure (CHF)

Exo-Check Exosome Antibody Array
322-EXO-FBS-50A-1	Gentaur Genprice	100 µg	EUR 469.2

Human Notch Homolog 2 (NOTCH2) ELISA Kit
20-abx152540	Abbexa	EUR 8853.60 EUR 4719.60 EUR 1093.20	10 × 96 tests 5 × 96 tests 96 tests

Human Notch Homolog 3 (NOTCH3) CLIA Kit
20-abx495887	Abbexa	EUR 10282.80 EUR 5472.00 EUR 1262.40	10 × 96 tests 5 × 96 tests 96 tests

Human Notch Homolog 2 (NOTCH2) CLIA Kit
20-abx495888	Abbexa	EUR 10282.80 EUR 5472.00 EUR 1262.40	10 × 96 tests 5 × 96 tests 96 tests

Human Notch Homolog 4 (NOTCH4) CLIA Kit
20-abx495889	Abbexa	EUR 10282.80 EUR 5472.00 EUR 1262.40	10 × 96 tests 5 × 96 tests 96 tests

Human Notch Homolog 3 (NOTCH3) ELISA Kit
20-abx258645	Abbexa	EUR 8853.60 EUR 4719.60 EUR 1093.20	10 × 96 tests 5 × 96 tests 96 tests

Human Notch Homolog 4 (NOTCH4) ELISA Kit
20-abx258646	Abbexa	EUR 8853.60 EUR 4719.60 EUR 1093.20	10 × 96 tests 5 × 96 tests 96 tests

Human Notch Homolog 2 (NOTCH2) ELISA Kit
DLR-NOTCH2-Hu-48T	DL Develop	48T	EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Notch Homolog 2 (NOTCH2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Notch Homolog 2 (NOTCH2) ELISA Kit
DLR-NOTCH2-Hu-96T	DL Develop	96T	EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Notch Homolog 2 (NOTCH2) in samples from tissue homogenates, cell lysates or other biological fluids.

Nori® Human Notch-1 ELISA Kit
GR106384	Genorise Scientific	96-well	EUR 553.2

Notch Homolog 3 (NOTCH3) Polyclonal Antibody (Human)
4-PAL147Hu01	Cloud-Clone	EUR 313.20 EUR 3280.80 EUR 811.20 EUR 396.00 EUR 264.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Notch Homolog 3 (NOTCH3)

Notch Homolog 2 (NOTCH2) Polyclonal Antibody (Human)
4-PAL148Hu01	Cloud-Clone	EUR 314.40 EUR 3296.40 EUR 814.80 EUR 397.20 EUR 264.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Notch Homolog 2 (NOTCH2)

We did not find any security issues until 17 days after intravitreal injection RO4929097. Conclusion: Inhibiting Notch signaling may be an effective way to prevent retinal fibrosis. This study is of clinical significance in developing treatments to prevent fibrosis in proliferative vitreoretinopathy, proliferative diabetic retinopathy and wet age-related macular degeneration.