Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

Background: Line of HIF-1α / Notch signaling regulate cell proliferation, apoptosis, and metabolism of the intervertebral disc (IVD) and is involved in disc degeneration. The nucleus pulposus (NP) is an important structure adjacent to the IVD. However, the role of HIF-1α / Notch signaling pathway in NP cells obtained from patients with different Modic changes (MC) is still unclear. The purpose of this study was to investigate the role of HIF-1α and components of the Notch pathway in NP obtained from patients with various MC.


Methods: A total of 85 NP tissue samples collected from patients who underwent diskectomy for the treatment of low back pain. NP network were divided into four groups based on the adjacent endplate degeneration, namely, MC I, II, III, and negative MC group. Expression of HIF-1α and Notch-related component is measured and compared.


Results: The expression of HIF-1α, Notch1 and Notch2 gradually increased in the first MC and MC II group than in the negative group MC. HIF-1α and Notch-related components are rarely detected in MC group III.
Conclusion: The expression of HIF-1α / Notch increased in cells of patients with NP MC MC I and II. HIF-1α and components related to the potential biomarkers Notch and HIF-1α / Notch signaling pathway may serve as a promising therapeutic target for disc degeneration in patients with MC.

Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain
Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

Targeting the Notch signaling pathway and TGF-β to prevent retinal fibrosis in vitro and in vivo

Rationale: Notch and transforming growth factor-β (TGFβ) two signaling pathways that control intracellular mechanisms of fibrosis in general, but if they play a major role in retinal fibrosis is less clear. Here we learn how these two signal pathways regulate cell Müller-dominated retinal fibrosis in vitro and in vivo. Methods: Human cells MIO-M1 Müller and TGFβ1 treated with Notch ligands, either alone or in combination. Western blot was conducted to study the changes protease γ-Secretase, Notch downstream effectors, endogenous TGFβ1, Smad3 phosphorylated (p-Smad3) and the extracellular matrix (ECM) proteins.

We also studied the effects RO4929097, a selective inhibitor of γ-Secretase, the ECM protein expression after ligand stimulation. Müller cell viability and cytotoxicity was studied by AlamarBlue to test the cytotoxicity of lactate. Finally, we studied the changes in Notch and TGFβ signaling and test the effect of an intravitreal injection of Notch pathway inhibitors RO4929097 on retinal fibrosis resulting from sodium iodate (NaIO3) -induced retinal injury in rats.

We also studied the security of RO4929097 intravitreal injection of normal mice. Results: Treatment of Muller cells with protease deregulated Notch ligand and Notch γ-Secretase downstream effector, with an increased expression of endogenous TGFβ1, TGFβ receptor and p-Smad3. TGFβ1 regulated expression of proteins associated with both signal paths in the same way. Notch ligands and TGFβ1 have an additive effect on ECM protein overexpression in Müller cells were inhibited by RO4929097. Notch and TGFβ ligand stimulates proliferation of Müller cells were inhibited by RO4929097 without damaging the cells. NaIO3-induced injury to the retina enabled both Notch and TGFβ signaling pathway in vivo intravitreal injection RO4929097 prevented gliosis Müller cells and inhibit excessive ECM proteins in this murine model.

Human Notch Signaling Pathway Notch1/CSL Reporter Cell Line-HEK293

ABC-RC0116 1 vial Ask for price
Description: Human Notch Signaling Pathway Notch1/CSL Reporter Cell Line is derived from HEK293. Application: • Monitor Notch signaling pathway activity.• Screen for activators or inhibitors of the Notch signaling pathway.

Notch1/CSL Reporter Kit (Notch Signaling Pathway)

60509 500 rxns.
EUR 590
Description: The Notch Pathway Reporter kit is designed for monitoring the activity of Notch signaling pathway in the cultured cells. The kit contains the transfection-ready expression vector for Notch1 with the entire extracellular domain deleted (Notch1DE). Inside the cells, the Notch1DE can be cleaved by -secretase and active Notch1 NICD is released to nucleus. The kit also contains a CSL (CBF1/RBP-J) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized CSL responsive element upstream of a minimal promoter. The CSL (CBF1/RBP-J) reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutivelyexpressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway specific effects and background luciferase activity.

Notch Signaling Pathway Notch1/CSL Reporter - HEK293 Cell Line

60652 2 vials
EUR 2175
Description: The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the Notch1 E can be cleaved by γ-secretase. The active Notch1 NICD is released to nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway.

Notch Signaling Pathway Notch1/CSL Report Cell Line-HEK293

ABC-RC123D 1 vial Ask for price
Description: The Notch CSL Reporter andndash; HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the Notch1 E can be cleaved by andgamma;-secretase. The active Notch1 NICD is released to nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway.

Transfection Collection™ : Notch1/CSL Transient Pack (Notch Signaling Pathway)

79285 500 rxns.
EUR 715
Description: The Notch1/CSL Transient Packis designed to provide the tools necessary for transiently transfecting and monitoring the activity of the Notch signaling pathway in HEK293 cultured cells. The kit contains transfection-ready vectors containing firefly luciferase as a Notch pathway-responsive reporter and constitutively expressing Renilla luciferase as a transfection control. It also includes the Dual Luciferase detection reagents to detect both luciferase activities and specialized medium for growing and assaying HEK293 cells._x000D_The key to the Notch1/CSL Transient Pack is the expression vector for NOTCH1 that has a deletion of the entire extracellular domain (Notch1DE). Inside the cells, the NOTCH1 DE can be cleaved by γ-secretase and active NOTCH1 NICD is released into the nucleus. The kit also contains CSL (CBF1/RBP-Jk) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains the firefly luciferase gene under the control of multimerized CSL responsive elements upstream of a minimal promoter. The CSL (CBF1/RBP-Jk) reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The pack also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway specific effects and background luciferase activity._x000D_Additionally, the pack includes cell culture medium (BPS Medium 1) that has been optimized for use with HEK293 cells*. BPS Medium 1 includes MEM medium, 10% fetal bovine serum, 1% non-essential amino acids, sodium pyruvate, and 1% Pen/Strep. Finally, the pack provides the Dual Luciferase (Firefly-Renilla) Assay System. These luciferase reagents provide highly sensitive, stable detection of firefly luciferase activity and Renilla luciferase activity. The dual luciferase reagents can be used directly in cells in growth medium, and can be detected with any luminometer; automated injectors are not required. _x000D_*Note: the kit may be used with other cell lines than HEK293, but an alternate cell culture medium may be required for optimal cell growth,

Cancer MicroRNA qPCR Array

RA610A-1 10 profiles
EUR 1406.4

LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles

RA900A-1 20 profiles
EUR 1020

Mouse LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles

RA930A-1 20 profiles
EUR 1020

LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles

RA910A-1 20 profiles
EUR 1329.6

Human Statin Signaling Library

HSTAT-I 1 set
EUR 657.6

Human BMP Signaling Primer Library

HBMP-I 1 set
EUR 657.6

Human WNT Signaling Primer Library

HWNT-I 1 set
EUR 657.6

Human MAP Kinase Signaling Library

HMAP-I 1 set
EUR 657.6

Human Ras Signaling Primer Library

HRAS-I 1 set
EUR 657.6

Human TNF Signaling Primer Library

HTNF-I 1 set
EUR 657.6

Human p53 Signaling Primer Library

HTPS-I 1 set
EUR 540

Human EGFR Signaling Primer Library

HEGFR-I 1 set
EUR 657.6

Human ERBB Signaling Primer Library

HERBB-I 1 set
EUR 657.6

Human BDNF Signaling Primer Library

HBDNF-I 1 set
EUR 657.6

Human cAMP Signaling Primer Library

HCAMP-I 1 set
EUR 657.6

Human CREB Signaling Primer Library

HCREB-I 1 set
EUR 657.6

Human VEGF Signaling Primer Library

HVEGF-I 1 set
EUR 657.6

Human PDGF Signaling Primer Library

HPDGF-I 1 set
EUR 657.6

Human GDNF Signaling Primer Library

HGDNF-I 1 set
EUR 657.6

Human IL17 Signaling Primer Library

HIL17-I 1 set
EUR 657.6

Human SMAD Signaling Primer Library

HSMAD-I 1 set
EUR 657.6

Human Hippo Signaling Primer Pathway

HHPO-I 1 set
EUR 657.6

Human Hypoxia Signaling Primer Library

HHYP-I 1 set
EUR 657.6

Human Insulin Signaling Primer Library

HINS-I 1 set
EUR 657.6

Human Estrogen Signaling Primer Library

HESR-I 1 set
EUR 774

Human Androgen Signaling Primer Library

HAND-I 1 set
EUR 657.6

Human Hedgehog Signaling Primer Library

HHOG-I 1 set
EUR 774

Human Integrin Signaling Primer Library

HINT-I 1 set
EUR 657.6

Human JAK/STAT Signaling Primer Library

HJAK-I 1 set
EUR 657.6

Human TGF Beta Signaling Primer Library

HTGFB-I 1 set
EUR 657.6

Human PI3K-AKT Signaling Primer Library

HAKT-I 1 set
EUR 540

Human Suppressors Of Cytokine Signaling 1

E01A7752 96T
EUR 700
Description: ELISA

Human Nitric Oxide Signaling Primer Library

HNOS-I 1 set
EUR 657.6

Human FGF Receptor Signaling Primer Library

HFGF-I 1 set
EUR 774

Human Breast Cancer Signaling Primer Library

HBRCA-I 1 set
EUR 657.6

Human Neurotransmitter Signaling Primer Library

HNTS-I 1 set
EUR 657.6

Human Focal Adhesion Signaling Primer Library

HFCA-I 1 set
EUR 657.6

Human Agouti signaling protein(ASIP) ELISA kit

E01A1103 96T
EUR 700
Description: ELISA

Human Agouti- signaling protein, ASIP ELISA KIT

ELI-24110h 96 Tests
EUR 988.8

Human Agouti signaling protein(ASIP) ELISA kit

E01A1721-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Agouti signaling protein(ASIP) ELISA kit

E01A1721-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Agouti signaling protein(ASIP) ELISA kit

E01A1721-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Agouti Signaling Protein (ASIP) ELISA Kit

abx384564-96tests 96 tests
EUR 1093.2

Human Suppressor of cytokine signaling 1 (SOCS1)

1-CSB-YP022388HU
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  • 100ug
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  • 1MG
  • 200ug
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  • 50ug
Description: Recombinant Human Suppressor of cytokine signaling 1(SOCS1) expressed in Yeast

Human Suppressor of cytokine signaling 1 (SOCS1)

1-CSB-EP022388HU
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  • 100ug
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Description: Recombinant Human Suppressor of cytokine signaling 1(SOCS1) expressed in E.coli

Human Suppressor of cytokine signaling 2 (SOCS2)

1-CSB-EP022389HU
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  • 100ug
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Description: Recombinant Human Suppressor of cytokine signaling 2(SOCS2) expressed in E.coli

Human Virus Induced Signaling Adapter ELISA Kit

IHUVISAKT each
EUR 733
Description: Human Virus Induced Signaling Adapter ELISA Kit

Agouti Signaling Protein (ASP) (87-132) amide (Human)

003-54 100 μg
EUR 316.44

Human Actin Cytoskeleton Signaling Primer Library

HACS-I 1 set
EUR 657.6

Human B-Cell Receptor Signaling Primer Library

HBCR-I 1 set
EUR 657.6

Human T-Cell Receptor Signaling Primer Library

HTCR-I 1 set
EUR 657.6

ASIP (untagged)-Human agouti signaling protein (ASIP)

SC303053 10 µg Ask for price

Human Interferon Type I Signaling Primer Library

HIFN-I 1 set
EUR 657.6

Human Interferon Type II Signaling Primer Library

HIFN-II 1 set
EUR 657.6

Human Regulator of G-protein signaling 2 (RGS2)

1-CSB-EP019651HU
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  • 100ug
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Description: Recombinant Human Regulator of G-protein signaling 2(RGS2) expressed in E.coli

Human Regulator of G-protein signaling 5 (RGS5)

1-CSB-EP019657HU
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  • 100ug
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Description: Recombinant Human Regulator of G-protein signaling 5(RGS5) expressed in E.coli

Human Regulator of G-protein signaling 7 (RGS7)

1-CSB-EP019659HU
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  • 100ug
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Description: Recombinant Human Regulator of G-protein signaling 7(RGS7) expressed in E.coli

Human Virus Induced Signaling Adapter (VISA) Protein

20-abx655487
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  • 100 ug
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  • 1 mg
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  • 50 ug

Human Regulator of G-protein signaling 10 (RGS10)

1-CSB-EP019642HU
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  • 100ug
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Description: Recombinant Human Regulator of G-protein signaling 10(RGS10) expressed in E.coli

Human Regulator of G-protein signaling 20 (RGS20)

1-CSB-EP019652HU
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  • 100ug
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Description: Recombinant Human Regulator of G-protein signaling 20(RGS20) expressed in E.coli

Human Toll-like Receptor Signaling Primer Library

HTLR-I 1 set
EUR 657.6

Canopy FGF Signaling Regulator 1 Human Recombinant

rAP-2948 Inquiry Ask for price

Canopy FGF Signaling Regulator 4 Human Recombinant

rAP-2949 Inquiry Ask for price

DAP10 Signaling Fragment

5-01031 4 x 1mg Ask for price

Human Suppressor of cytokine signaling 3 ELISA Kit

EK3869 96 tests
EUR 599

Human Suppressor of cytokine signaling 2 ELISA Kit

EK3343 96 tests
EUR 599

Human Suppressor of cytokine signaling 1 ELISA Kit

EK3345 96 tests
EUR 599

Human Virus Induced Signaling Adapter (VISA) CLIA Kit

EKU12000-48T 48T
EUR 666.82

Human Virus Induced Signaling Adapter (VISA) CLIA Kit

EKU12000-5x96T 5x96T
EUR 4524.85

Human Virus Induced Signaling Adapter (VISA) CLIA Kit

EKU12000-96T 96T
EUR 952.6

Human Virus Induced Signaling Adapter (VISA) CLIA Kit

EKN53111-48T 48T
EUR 414.89

Human Virus Induced Signaling Adapter (VISA) CLIA Kit

EKN53111-5x96T 5x96T
EUR 2815.33

Human Virus Induced Signaling Adapter (VISA) CLIA Kit

EKN53111-96T 96T
EUR 592.7

Human Virus Induced Signaling Adapter (VISA) CLIA Kit

20-abx493783
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Suppressor Of Cytokine Signaling 3 Human Recombinant

rAP-4134 Inquiry Ask for price

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

DLR-VISA-Hu 96T
EUR 463
Description: tissue homogenates, cell lysates or other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

DLR-VISA-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Virus Induced Signaling Adapter (VISA) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

DLR-VISA-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Virus Induced Signaling Adapter (VISA) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

DL-VISA-Hu 96T
EUR 441
Description: tissue homogenates, cell lysates or other biological fluids.

Human Suppressors Of Cytokine Signaling 3 ELISA kit

E01S0137-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Suppressors Of Cytokine Signaling 3 ELISA kit

E01S0137-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Suppressors Of Cytokine Signaling 3 ELISA kit

E01S0137-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Suppressors Of Cytokine Signaling 1 ELISA kit

E01S0138-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Suppressors Of Cytokine Signaling 1 ELISA kit

E01S0138-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Suppressors Of Cytokine Signaling 1 ELISA kit

E01S0138-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Suppressors Of Cytokine Signaling 3 ELISA kit

E01A7751 96T
EUR 700
Description: ELISA

Human VISA(Virus Induced Signaling Adapter) ELISA Kit

ELK4587-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human VISA. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human VISA. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human VISA, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human VISA in the samples is then determined by comparing the OD of the samples to the standard curve.

Human VISA(Virus Induced Signaling Adapter) ELISA Kit

ELK4587-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human VISA. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human VISA. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human VISA, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human VISA in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

EKU08148-48T 48T
EUR 555.66

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

EKU08148-5x96T 5x96T
EUR 3770.55

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

EKU08148-96T 96T
EUR 793.8

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

EKN49259-48T 48T
EUR 345.73

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

EKN49259-5x96T 5x96T
EUR 2346.03

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

EKN49259-96T 96T
EUR 493.9

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

EK17277 96Т
EUR 768

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

20-abx153482
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

RD-VISA-Hu-48T 48T
EUR 452.7
Description: tissue homogenates, cell lysates and other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

RD-VISA-Hu-48Tests 48 Tests
EUR 625.2

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

RD-VISA-Hu-96T 96T
EUR 646.7
Description: tissue homogenates, cell lysates and other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

RD-VISA-Hu-96Tests 96 Tests
EUR 867.6

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

RDR-VISA-Hu-48T 48T
EUR 475.34
Description: tissue homogenates, cell lysates and other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

RDR-VISA-Hu-48Tests 48 Tests
EUR 652.8

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

RDR-VISA-Hu-96T 96T
EUR 679.04
Description: tissue homogenates, cell lysates and other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

RDR-VISA-Hu-96Tests 96 Tests
EUR 907.2

Human Suppressors Of Cytokine Signaling 1 ELISA Kit

IHUSOCS1KT each
EUR 733
Description: Human Suppressors Of Cytokine Signaling 1 ELISA Kit

Human Suppressors Of Cytokine Signaling 2 ELISA Kit

IHUSOCS2KT each
EUR 733
Description: Human Suppressors Of Cytokine Signaling 2 ELISA Kit

Human Suppressors Of Cytokine Signaling 3 ELISA Kit

IHUSOCS3KT each
EUR 700
Description: Human Suppressors Of Cytokine Signaling 3 ELISA Kit

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

SEC597Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Virus Induced Signaling Adapter (VISA) in Tissue homogenates, cell lysates and other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

SEC597Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Virus Induced Signaling Adapter (VISA) in Tissue homogenates, cell lysates and other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

SEC597Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Virus Induced Signaling Adapter (VISA) in Tissue homogenates, cell lysates and other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

SEC597Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Virus Induced Signaling Adapter (VISA) in Tissue homogenates, cell lysates and other biological fluids.

Human Virus Induced Signaling Adapter (VISA) ELISA Kit

4-SEC597Hu
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  • 10 plates of 96 wells
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  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Virus Induced Signaling Adapter (VISA) in samples from Tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Regulator Of G Protein Signaling 4 ELISA kit

E01A7454 96T
EUR 700
Description: ELISA

Human Regulator Of G Protein Signaling 1 ELISA kit

E01A7669 96T
EUR 700
Description: ELISA

Human Regulator Of G Protein Signaling 4 ELISA kit

E01R0039-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Regulator Of G Protein Signaling 4 ELISA kit

E01R0039-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Regulator Of G Protein Signaling 4 ELISA kit

E01R0039-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Regulator Of G Protein Signaling 9 ELISA Kit

ELA-E2141h 96 Tests
EUR 988.8

Human Regulator Of G Protein Signaling 6 ELISA Kit

IHURGS6KT each
EUR 733
Description: Human Regulator Of G Protein Signaling 6 ELISA Kit

ASIP (GFP-tagged) - Human agouti signaling protein (ASIP)

RG222654 10 µg Ask for price

Human Regulator of G-protein signaling 19 ELISA Kit

EK4664 96 tests
EUR 659

Human Regulator of G-protein signaling 1 ELISA Kit

EK2636 96 tests
EUR 636

BMP signaling agonist sb4

T7799-10mg 10mg Ask for price
Description: BMP signaling agonist sb4

BMP signaling agonist sb4

T7799-1g 1g Ask for price
Description: BMP signaling agonist sb4

BMP signaling agonist sb4

T7799-1mg 1mg Ask for price
Description: BMP signaling agonist sb4

BMP signaling agonist sb4

T7799-50mg 50mg Ask for price
Description: BMP signaling agonist sb4

BMP signaling agonist sb4

T7799-5mg 5mg Ask for price
Description: BMP signaling agonist sb4

Recombinant Human Regulator of G-Protein Signaling 2

7-06115 1µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 2

7-06116 5µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 2

7-06117 50µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 5

7-06118 5µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 5

7-06119 25µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 5

7-06120 1mg Ask for price

Recombinant Human Regulator of G-Protein Signaling 4

7-06121 2µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 4

7-06122 10µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 4

7-06123 1mg Ask for price

Recombinant Human Regulator of G-Protein Signaling 10

7-06124 5µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 10

7-06125 25µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 10

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Recombinant Human Regulator of G-Protein Signaling 16

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Recombinant Human Regulator of G-Protein Signaling 16

7-06128 10µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 16

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Recombinant Human Regulator of G-Protein Signaling 19

7-06130 5µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 19

7-06131 20µg Ask for price

Recombinant Human Regulator of G-Protein Signaling 19

7-06132 1mg Ask for price

We did not find any security issues until 17 days after intravitreal injection RO4929097. Conclusion: Inhibiting Notch signaling may be an effective way to prevent retinal fibrosis. This study is of clinical significance in developing treatments to prevent fibrosis in proliferative vitreoretinopathy, proliferative diabetic retinopathy and wet age-related macular degeneration.

Anthony

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