Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Plastic changes in the anterior cingulate cortex (ACC) is very important in hypersensitivity to pain caused by peripheral nerve injury. The Notch signaling pathway has been shown to regulate differentiation and synaptic transmission. Therefore, this study was to investigate the function of Notch signaling pathway in the ACC during nociceptive transmission caused by neuropathy pain

.We adopt Western boltting, N- [N- (3,5-difluorophenacetyl) l-Alanyl] -S- Phenylglycine t-butyl ester (dAPT) microinjections, RNA interference targeting Notch1, hairy and enhancer of split (Hes) 1 or Hes5, electrophysiological recording and behavioral tests to verify the relationship between Notch signaling in the ACC and neuropathic pain in rats adult male Sprague Dawley .Levels of Notch intracellular domain (NICD) increased in the ACC at day 7 after chronic constriction injury (CCI) operation or spared nerve injury (SNI).

Meanwhile, the mRNA level of Notch signaling downstream effector Hes1 Hes5 mRNA increased while the rate unchanged. Injection of DAPT, a γ-Secretase (the key enzyme involved in the Notch pathway) inhibitors, ACC to significantly reversed neuropathic pain behavior. Intra-ACC injection of short hairpin RNA (shRNA) -Notch reduce the expression of NICD and lower potentiation of synaptic transmission in the ACC. In addition, the perception of pain is also addressed in mice undergoing CCI or SNI. This process is mainly mediated by Hes1 downstream effectors, but not Hes5.Based this result, activation of the Notch / Hes1 signaling pathway in the ACC participated in the development of neuropathic pain, suggesting that Notch pathway may be a new therapeutic target to treat chronic pain.

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain
Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

[Decrease in long chains MALAT1 non-coding RNA expression and increased expression of HSA-miR155-3p involved in the regulation of Notch signaling pathway in patients with rheumatoid arthritis]

Objective To investigate the expression of a long chain of non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and HSA-miR155-3p in patients with rheumatoid arthritis (RA) and their relationship with the Notch signaling pathway, and explore the possibility of RA pathogenesis. Method peripheral blood of patients with RA (RA group) and healthy controls (group NC) was used to screen differentially expressed mRNA by lncRNA and high-throughput gene sequencing.

Reverse-transcription PCR is used to detect the expression of lncRNA MALAT1, HSA-miR155-3p and Notch signaling pathway receptor ligands. Results lncRNA sequencing analysis showed a total of 9158 lncRNAs are expressed differently. Gene ontology (GO) annotation of functional classification revealed that differential mRNA is expressed mainly involved in inflammatory immune response, cellular transcriptional regulation and so on.

path analysis proves that the differentially expressed mRNA was significantly associated with genes involved in rheumatoid arthritis, cellular aging, and the Notch signaling pathway. According to the prediction of cis and trans, Jagged1-2, Delta1-2 and Notch1-2 probably closely related to RA. MALAT1 the RA group was lower than in group NC, and HSA-miR155-3p expression was significantly higher than in the NC group.

PLATEMAX ULTRA CLEAR PEELABLE HEAT SEALING FILM FOR QPCR. 100/500

HS-150-QPCR 100/pk
EUR 318
Description: Sealing Products; Sealing films - Axygen

LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles

RA910A-1 20 profiles
EUR 1108

Pig Notch Homolog 1 ELISA kit

E07N0594-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Notch Homolog 1 ELISA kit

E07N0594-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Notch Homolog 1 ELISA kit

E07N0594-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Nylon Array

MVSNGA110 10 Slides
EUR 226

Nylon Array

MVSNGA120 20 Slides
EUR 363

Array Designer

AD6 1
EUR 4248

Guinea pig Notch Homolog 1 ELISA kit

E05N0594-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Notch Homolog 1 ELISA kit

E05N0594-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Notch Homolog 1 ELISA kit

E05N0594-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Universal qPCR Mixture

QPCR1000-UNIV 4X1.25ml
EUR 276.2

Green qPCR SuperMix

20-abx098031
  • EUR 1038.00
  • EUR 439.00
  • EUR 634.00
  • 15 ml
  • 1 ml
  • 5 ml

Probe qPCR SuperMix

20-abx098040
  • EUR 1038.00
  • EUR 439.00
  • EUR 634.00
  • 15 ml
  • 1 ml
  • 5 ml

Mouse Cell Array

17-701 1 pack
EUR 191
Description: Mouse cell lines (A-20, EL4, L1210, NIH/3T3, P815 and RAW 264.7)

Notch 1 Antibody

abx139789-01mg 0.1 mg
EUR 356

Notch 1 Antibody

48766-100ul 100ul
EUR 333

Notch 1 Antibody

48766-50ul 50ul
EUR 239

Notch 1 antibody

10R-6539 50 ug
EUR 192
Description: Mouse monoclonal Notch 1 antibody

Notch 1 antibody

20R-1749 100 ug
EUR 673
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 antibody

70R-31090 100 ug
EUR 327
Description: Rabbit polyclonal Notch 1 antibody

Notch 2 antibody

70R-31091 100 ug
EUR 327
Description: Rabbit polyclonal Notch 2 antibody

Notch 1 antibody

70R-12158 100 ug
EUR 403
Description: Rabbit polyclonal Notch 1 antibody

pGreenFire1-Notch (plasmid)

TR020PA-1 10 ug
EUR 786

pGreenFire1-Notch (virus)

TR020VA-1 >2 x 10^6 IFUs
EUR 786

Notch 1 Antibody

3881-100
EUR 316

Notch 1 Antibody

3881-30T
EUR 146

anti-Notch 2

YF-PA24259 50 ul
EUR 334
Description: Mouse polyclonal to Notch 2

Green qPCR SuperMix UDG

20-abx098032
  • EUR 1135.00
  • EUR 453.00
  • EUR 662.00
  • 15 ml
  • 1 ml
  • 5 ml

Top Green qPCR SuperMix

20-abx098033
  • EUR 829.00
  • EUR 217.00
  • EUR 1135.00
  • EUR 411.00
  • 15 ml
  • 1 ml
  • 25 ml
  • 5 ml

Tip Green qPCR SuperMix

20-abx098034
  • EUR 968.00
  • EUR 230.00
  • EUR 1330.00
  • EUR 467.00
  • 15 ml
  • 1 ml
  • 25 ml
  • 5 ml

Library Quantification qPCR SuperMix

20-abx098896
  • EUR 230.00
  • EUR 411.00
  • 1 ml
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Entrans qPCR Probe Kit

RK21209 40 RXN Ask for price

Entrans qPCR Probe Set

RK21210 40 RXN Ask for price

qPCR Control Template Kit

G929 100 rxns
EUR 148

Eva QPCR SuperMix Kit

K5052200 200 reactions
EUR 211
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Eva QPCR SuperMix Kit

K5052400 400 reactions
EUR 320
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Pro QPCR SuperMix Kit

K5053200 200 reactions
EUR 188
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Pro QPCR SuperMix Kit

K5053400 400 reactions
EUR 299
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Neural Lineage qPCR Profiler

RA500A-1 10 reactions
EUR 999

Regulatory RNA qPCR Profiler

RA950A-1 20 rxn
EUR 880

Lentivirus qPCR Quantification Kit

K1471-100 100 Rxns
EUR 298

Retrovirus qPCR Quantification Kit

K1472-100 100 Rxns
EUR 318

QPCR Positive Control Kit

M1126-100
EUR 403

Pig Agouti signaling protein(ASIP) ELISA kit

E07A1721-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Agouti signaling protein(ASIP) ELISA kit

E07A1721-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Agouti signaling protein(ASIP) ELISA kit

E07A1721-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Amino Particle Array Kit

APAK-3567-7K 7X1 mL
EUR 558
Description: Amino Particle Array KitGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Fluorescent Particle Array Kit

FPAK-4058--10K 10 mL
EUR 563
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Blue Particle Array Kit

PAK-3567-7K 7X1 mL
EUR 563
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Blue Particle Array Kit

PAK-4067-8K 8X1 mL
EUR 563
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Blue Particle Array Kit

PAK-5067-10K 10X1 mL
EUR 939
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Blue Particle Array Kit

PAK-5067-5A 5X1 mL
EUR 563
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Blue Particle Array Kit

PAK-5067-5B 5X1 mL
EUR 563
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Blue Particle Array Kit

PAK-7067-9K 9X1 mL
EUR 939
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CA125 antibody array kit

VArk-Lsx008 1 mg
EUR 664
Description: CA125 can be used as a tumor marker to identify the type of tumor and check if the treatment is working.

Ferritin antibody array kit

VArk-Lsx009 1 mg
EUR 419
Description: Used for detection of Ferritin

Microalbuminuria antibody array kit

VArk-Lsx010 1 mg
EUR 419
Description: Used to detect early signs of kidney damage

FDA Standard Tissue Array

T8234701-1 1 slides
EUR 214
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Tissue Array

T8234701-5 5 slides
EUR 654
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Human Cell Array I

17-601 1 pack
EUR 191
Description: Human cell lines (HEK293, A-431, A549, Hela S3, Hep G2 and MCF7)

Human Cell Array II

17-602 1 pack
EUR 191
Description: Human cell lines (HL-60, Jurkat, K-562, MOLT-4, Raji and THP-1)

Notch-1 ELISA Kit| Mouse Neurogenic locus notch homolog protein

EF014010 96 Tests
EUR 689

Polyclonal Notch 1 Antibody

AMM06725G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Notch 1 . This antibody is tested and proven to work in the following applications:

Anti-NOTCH 1 Antibody

A00033 200uL
EUR 478
Description: Rabbit Polyclonal NOTCH 1 Antibody. Validated in IHC, WB and tested in Human.

Anti-NOTCH 2 Antibody

A00518 200uL
EUR 486
Description: Rabbit Polyclonal NOTCH 2 Antibody. Validated in IHC, WB and tested in Human.

Notch 1 Antibody (APC)

abx139790-01mg 0.1 mg
EUR 425

Notch 1 Antibody (PE)

abx139791-01mg 0.1 mg
EUR 425

Notch 3 (NOTCH3) Antibody

20-abx214675
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Notch 1 Conjugated Antibody

C48766 100ul
EUR 397

Notch 1 Blocking Peptide

33R-10970 50 ug
EUR 191
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 70R-12158

Notch 3 antibody (PE)

61R-1343 100 ug
EUR 440
Description: Armenian Hamster monoclonal Notch3 antibody (PE)

Notch 4 antibody (PE)

61R-1344 25 ug
EUR 208
Description: Armenian Hamster monoclonal Notch4 antibody (PE)

Notch 1 antibody (PE)

61R-1347 100 ug
EUR 354
Description: Mouse monoclonal Notch 1 antibody (PE)

Notch 1 homolog antibody

70R-NR026 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal Notch 1 homolog antibody

Notch 2 homolog antibody

70R-NR027 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal Notch 2 homolog antibody

Notch 3 homolog antibody

70R-NR028 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal Notch 3 homolog antibody

Notch 4 homolog antibody

70R-NR029 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal Notch 4 homolog antibody

Notch 1 Blocking Peptide

33R-10562 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 20R-1749

Notch 1 Blocking Peptide

3881BP-50
EUR 153

Notch-1, mouse recombinant

7530-25
EUR 305

Notch-2, mouse recombinant

7531-25
EUR 305

Anti-NOTCH 2 Antibody

A1652-100
EUR 370

Anti-NOTCH 3 Antibody

A1653-100
EUR 370

Methylamp MS-qPCR Fast Kit

P-1028 200 Reactions
EUR 496.6
Description: fast delivery possible

SYBR Green qPCR Master Mix

HY-K0501 5 mL (500 rxns)
EUR 263

RT Master Mix for qPCR

HY-K0510 1 mL (100 rxns)
EUR 291

HotTaq Probe qPCR Mix (ROX)

BT11001 250rxn
EUR 109
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq Probe qPCR Mix (Capillary)

BT11003 250rxn
EUR 109
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq Probe qPCR Universal Mix

BT11004 250rxn
EUR 123
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq EvaGreen qPCR Mix (ROX)

BT11101 250rxn
EUR 123
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq EvaGreen qPCR Mix (Capillary)

BT11103 250rxn
EUR 123
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq EvaGreen qPCR Universal Mix

BT11104 250rxn
EUR 138
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

cDNA Synthesis SuperMix for qPCR

20-abx09801920ulSystems
  • EUR 690.00
  • EUR 565.00
  • 100 rxns ×20 ul Systems
  • 50 rxns × 20 ul Systems

TaqProbe 5X qPCR MasterMix-Multiplex

MasterMix-5PM 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213

BrightGreen 5X qPCR MasterMix-ROX

MasterMix-5R 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213

BrightGreen 2X qPCR MasterMix-iCycler

MasterMix-iC 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

BrightGreen 2X qPCR MasterMix-iCycler

MasterMix-iC-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 376

KiloGreen 2X qPCR MasterMix-iCycler

MasterMix-KC 4 x 1.25 ml - 500 reactions (20 ul)
EUR 140

KiloGreen 2X qPCR MasterMix-ROX

MasterMix-KR 4 x 1.25 ml - 500 reactions (20 ul)
EUR 140

BrightGreen miRNA qPCR MasterMix-iCycler

MasterMix-mC 4 x 1.25 ml for 500 reactions
EUR 151

BrightGreen miRNA qPCR MasterMix-ROX

MasterMix-mR 4 x 1.25 ml for 500 reactions
EUR 151

TaqProbe 2X qPCR MasterMix-ROX

MasterMix-P 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

TaqProbe 2X qPCR MasterMix-iCycler

MasterMix-PC 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

TaqProbe 2X qPCR MasterMix-Multiplex

MasterMix-PM 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

BrightGreen 2X qPCR MasterMix-ROX

MasterMix-R 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

BrightGreen 2X qPCR MasterMix-ROX

MasterMix-R-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 376

BrightGreen 5X qPCR MasterMix-iCycler

MasterMix-5C 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213

TaqProbe 5X qPCR MasterMix-ROX

MasterMix-5P 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213

TaqProbe 5X qPCR MasterMix-iCycler

MasterMix-5PC 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213

Power Eva QPCR SuperMix Kit

K5057200 200 reactions
EUR 188
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Power Eva QPCR SuperMix Kit

K5057400 400 reactions
EUR 320
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

AceQ qPCR Probe Master Mix

Q112-02 500 rxn (20 μl/rxn)
EUR 221

AceQ qPCR Probe Master Mix

Q112-03 2500 rxn (20 μl/rxn)
EUR 646

Pig Suppressors Of Cytokine Signaling 3 ELISA kit

E07S0137-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 3 ELISA kit

E07S0137-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 3 ELISA kit

E07S0137-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 1 ELISA kit

E07S0138-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 1 ELISA kit

E07S0138-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 1 ELISA kit

E07S0138-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Agouti signaling protein(ASIP) ELISA kit

E05A1721-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Guinea pig Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Agouti signaling protein(ASIP) ELISA kit

E05A1721-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Guinea pig Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Agouti signaling protein(ASIP) ELISA kit

E05A1721-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Notch-1(Neurogenic locus notch homolog protein 1) ELISA Kit

EM1527 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)

T8234708-2 2 slides
EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)

T8234708-5 5 slides
EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Glutathione Blue Particle Array Kit

GSHPAK--5067-4K 4X1 mL
EUR 791
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Blue Particle Array Kit

CPAK-10067--13K 13X1 mL
EUR 949
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-3067--7K 7X1 mL
EUR 563
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-3567--4K 4X1 mL
EUR 350
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-3567--7K 7X1 mL
EUR 563
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-4067--8K 8X1 mL
EUR 563
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-5067--10K 10 mL
EUR 939
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Blue Particle Array Kit

CPAK-5067--5A 5X1 mL
EUR 563
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Blue Particle Array Kit

CPAK-5067--5B 5X1 mL
EUR 563
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Yellow Particle Array Kit

CPAK-7052--3K 3X1 mL
EUR 405
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Yellow Particle Array Kit

CPAK-7052--6K 6x1 mL
EUR 695
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Blue Particle Array Kit

CPAK-7067--9K 9X1 mL
EUR 939
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

HIV-P24 antigen array kit

VArk-Lsx001 unit Ask for price
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood.

HCV core antigen array kit

VArk-Lsx002 unit Ask for price
Description: Measure the HCV core protein.

Procalcitonin (PCT) Antigen array kit

VArk-Lsx004 1 mg
EUR 811
Description: Used as an early and highly accurate biomarker for sepsis and infection.

NT-pro BNP array kit

VArk-Lsx007 1 mg
EUR 1489
Description: To help detect, diagnose, and evaluate the severity of congestive heart failure (CHF)

Streptavidin Blue Array Particle Kit

SVPAK-5067--10K 10 mL
EUR 994
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Streptavidin Blue Array Particle Kit

SVPAK-5067--5A 5X1 mL
EUR 588
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Streptavidin Blue Array Particle Kit

SVPAK-5067--5B 5X1 mL
EUR 588
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

UV Carboxyl Particle Array Kit

UVCPAK--5042-14K 14X1 mL
EUR 1278
Description: UltraRainbow Fluorescent Particlesare calibration particles that help you to determine if a flow cytometer is properly aligned and has a clean flow cell with no fluidic blockage. Using SPHERO? Alignment Particles, the coefficients of variation (CVs), peak channels, and histogram distributions can be measured to determine the alignment and functionality of the flow cytometer.

Exo-Check Exosome Antibody Array

EXORAY200A-4 4 arrays
EUR 540

Exo-Check Exosome Antibody Array

EXORAY210A-8 8 arrays
EUR 980

Recombinant Notch Homolog 3 (NOTCH3)

4-RPL147Hu01
  • EUR 474.53
  • EUR 230.00
  • EUR 1504.48
  • EUR 568.16
  • EUR 1036.32
  • EUR 380.00
  • EUR 3611.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Notch Homolog 3 expressed in: E.coli

Recombinant Notch Homolog 2 (NOTCH2)

4-RPL148Hu01
  • EUR 485.28
  • EUR 233.00
  • EUR 1544.80
  • EUR 581.60
  • EUR 1063.20
  • EUR 388.00
  • EUR 3712.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Notch Homolog 2 expressed in: E.coli

Recombinant Notch Homolog 4 (NOTCH4)

4-RPL149Hu01
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Notch Homolog 4 expressed in: E.coli

Recombinant Notch Homolog 4 (NOTCH4)

4-RPL149Ra01
  • EUR 528.29
  • EUR 244.00
  • EUR 1706.08
  • EUR 635.36
  • EUR 1170.72
  • EUR 416.00
  • EUR 4115.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Notch Homolog 4 expressed in: E.coli

Delta1 Notch ligand expression lines, Delta2 Jagged1, Jagged2 and receptor Notch1 and Notch2 in the RA group increases. Correlation analysis showed that HSA-miR155-3p is inversely proportional to MALAT1, HSA-miR155-3p is directly proportional to the Notch pathway Delta1, Jagged1, and MALAT1 is inversely proportional to Jagged2. Conclusions In patients with rheumatoid arthritis, lncRNA MALAT1 HSA-mir155-3p reduced and increased, which together regulate Notch signaling pathway changes.

Anthony

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