Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Plastic changes in the anterior cingulate cortex (ACC) is very important in hypersensitivity to pain caused by peripheral nerve injury. The Notch signaling pathway has been shown to regulate differentiation and synaptic transmission. Therefore, this study was to investigate the function of Notch signaling pathway in the ACC during nociceptive transmission caused by neuropathy pain

.We adopt Western boltting, N- [N- (3,5-difluorophenacetyl) l-Alanyl] -S- Phenylglycine t-butyl ester (dAPT) microinjections, RNA interference targeting Notch1, hairy and enhancer of split (Hes) 1 or Hes5, electrophysiological recording and behavioral tests to verify the relationship between Notch signaling in the ACC and neuropathic pain in rats adult male Sprague Dawley .Levels of Notch intracellular domain (NICD) increased in the ACC at day 7 after chronic constriction injury (CCI) operation or spared nerve injury (SNI).

Meanwhile, the mRNA level of Notch signaling downstream effector Hes1 Hes5 mRNA increased while the rate unchanged. Injection of DAPT, a γ-Secretase (the key enzyme involved in the Notch pathway) inhibitors, ACC to significantly reversed neuropathic pain behavior. Intra-ACC injection of short hairpin RNA (shRNA) -Notch reduce the expression of NICD and lower potentiation of synaptic transmission in the ACC. In addition, the perception of pain is also addressed in mice undergoing CCI or SNI. This process is mainly mediated by Hes1 downstream effectors, but not Hes5.Based this result, activation of the Notch / Hes1 signaling pathway in the ACC participated in the development of neuropathic pain, suggesting that Notch pathway may be a new therapeutic target to treat chronic pain.

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain
Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

[Decrease in long chains MALAT1 non-coding RNA expression and increased expression of HSA-miR155-3p involved in the regulation of Notch signaling pathway in patients with rheumatoid arthritis]

Objective To investigate the expression of a long chain of non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and HSA-miR155-3p in patients with rheumatoid arthritis (RA) and their relationship with the Notch signaling pathway, and explore the possibility of RA pathogenesis. Method peripheral blood of patients with RA (RA group) and healthy controls (group NC) was used to screen differentially expressed mRNA by lncRNA and high-throughput gene sequencing.

Reverse-transcription PCR is used to detect the expression of lncRNA MALAT1, HSA-miR155-3p and Notch signaling pathway receptor ligands. Results lncRNA sequencing analysis showed a total of 9158 lncRNAs are expressed differently. Gene ontology (GO) annotation of functional classification revealed that differential mRNA is expressed mainly involved in inflammatory immune response, cellular transcriptional regulation and so on.

path analysis proves that the differentially expressed mRNA was significantly associated with genes involved in rheumatoid arthritis, cellular aging, and the Notch signaling pathway. According to the prediction of cis and trans, Jagged1-2, Delta1-2 and Notch1-2 probably closely related to RA. MALAT1 the RA group was lower than in group NC, and HSA-miR155-3p expression was significantly higher than in the NC group.

Human Notch Signaling Pathway
HNOT-I 1 set
EUR 548
LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles
RA910A-1 20 profiles
EUR 1108
  • Category: Long Non-coding RNA Tools
Mouse Notch Signaling Primer Library
MNOT-I 1 set
EUR 548
PLATEMAX ULTRA CLEAR PERMANENT HEAT SEALING FILM FOR QPCR, 100/500
HS-100-QPCR 100/pk
EUR 318
Description: Sealing Products; Sealing films - Axygen
PLATEMAX ULTRA CLEAR PEELABLE HEAT SEALING FILM FOR QPCR. 100/500
HS-150-QPCR 100/pk
EUR 318
Description: Sealing Products; Sealing films - Axygen
Array Designer
AD6 1
EUR 4248
Nylon Array
MVSNGA110 10 Slides
EUR 226
Nylon Array
MVSNGA120 20 Slides
EUR 363
Pig Notch Homolog 1 ELISA kit
E07N0594-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Notch Homolog 1 ELISA kit
E07N0594-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Notch Homolog 1 ELISA kit
E07N0594-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig Notch Homolog 1 ELISA kit
E05N0594-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig Notch Homolog 1 ELISA kit
E05N0594-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig Notch Homolog 1 ELISA kit
E05N0594-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Green qPCR SuperMix
20-abx098031
  • EUR 1038.00
  • EUR 439.00
  • EUR 634.00
  • 15 ml
  • 1 ml
  • 5 ml
  • Shipped within 5-10 working days.
Probe qPCR SuperMix
20-abx098040
  • EUR 1038.00
  • EUR 439.00
  • EUR 634.00
  • 15 ml
  • 1 ml
  • 5 ml
  • Shipped within 5-10 working days.
Universal qPCR Mixture
QPCR1000-UNIV 4X1.25ml
EUR 276.2
  • Product category: PCR Related/PCR Premix (qPCR)/qPCR Premix + Taq
Notch 1 antibody
20R-1749 100 ug
EUR 673
Description: Rabbit polyclonal Notch 1 antibody
Notch 1 antibody
70R-12158 100 ug
EUR 403
Description: Rabbit polyclonal Notch 1 antibody
Notch 1 antibody
70R-31090 100 ug
EUR 327
Description: Rabbit polyclonal Notch 1 antibody
Notch 2 antibody
70R-31091 100 ug
EUR 327
Description: Rabbit polyclonal Notch 2 antibody
Notch 1 Antibody
3881-100
EUR 316
Notch 1 Antibody
3881-30T
EUR 146
Notch 1 antibody
10R-6539 50 ug
EUR 192
Description: Mouse monoclonal Notch 1 antibody
Notch 1 Antibody
48766-100ul 100ul
EUR 333
Notch 1 Antibody
48766-50ul 50ul
EUR 239
Notch 1 Antibody
abx139789-01mg 0.1 mg
EUR 356
  • Shipped within 5-12 working days.
pGreenFire1-Notch (plasmid)
TR020PA-1 10 ug
EUR 786
  • Category: Lentiviral Technology
pGreenFire1-Notch (virus)
TR020VA-1 >2 x 10^6 IFUs
EUR 786
  • Category: Lentiviral Technology
anti-Notch 2
YF-PA24259 50 ul
EUR 334
Description: Mouse polyclonal to Notch 2
Green qPCR SuperMix UDG
20-abx098032
  • EUR 1135.00
  • EUR 453.00
  • EUR 662.00
  • 15 ml
  • 1 ml
  • 5 ml
  • Shipped within 5-10 working days.
Top Green qPCR SuperMix
20-abx098033
  • EUR 829.00
  • EUR 217.00
  • EUR 1135.00
  • EUR 411.00
  • 15 ml
  • 1 ml
  • 25 ml
  • 5 ml
  • Shipped within 5-10 working days.
Tip Green qPCR SuperMix
20-abx098034
  • EUR 968.00
  • EUR 230.00
  • EUR 1330.00
  • EUR 467.00
  • 15 ml
  • 1 ml
  • 25 ml
  • 5 ml
  • Shipped within 5-10 working days.
Library Quantification qPCR SuperMix
20-abx098896
  • EUR 230.00
  • EUR 411.00
  • 1 ml
  • 5 ml
  • Shipped within 5-10 working days.
qPCR Control Template Kit
G929 100 rxns
EUR 148
Eva QPCR SuperMix Kit
K5052200 200 reactions
EUR 211
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.
Eva QPCR SuperMix Kit
K5052400 400 reactions
EUR 320
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.
Pro QPCR SuperMix Kit
K5053200 200 reactions
EUR 188
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.
Pro QPCR SuperMix Kit
K5053400 400 reactions
EUR 299
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.
QPCR Positive Control Kit
M1126-100
EUR 403
Neural Lineage qPCR Profiler
RA500A-1 10 reactions
EUR 999
  • Category: Lineage Profilers
Regulatory RNA qPCR Profiler
RA950A-1 20 rxn
EUR 880
  • Category: Long Non-coding RNA Tools
Lentivirus qPCR Quantification Kit
K1471-100 100 Rxns
EUR 298
Retrovirus qPCR Quantification Kit
K1472-100 100 Rxns Ask for price
Amino Particle Array Kit
APAK-3567-7K 7X1 mL
EUR 558
Description: Amino Particle Array KitGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.
Fluorescent Particle Array Kit
FPAK-4058--10K 10 mL
EUR 563
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.
Blue Particle Array Kit
PAK-3567-7K 7X1 mL
EUR 563
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.
Blue Particle Array Kit
PAK-4067-8K 8X1 mL
EUR 563
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.
Blue Particle Array Kit
PAK-5067-10K 10X1 mL
EUR 939
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.
Blue Particle Array Kit
PAK-5067-5A 5X1 mL
EUR 563
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.
Blue Particle Array Kit
PAK-5067-5B 5X1 mL
EUR 563
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.
Blue Particle Array Kit
PAK-7067-9K 9X1 mL
EUR 939
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.
FDA Standard Tissue Array
T8234701-1 1 slides
EUR 214
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
FDA Standard Tissue Array
T8234701-5 5 slides
EUR 654
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
CA125 antibody array kit
VArk-Lsx008 1 mg
EUR 664
Description: CA125 can be used as a tumor marker to identify the type of tumor and check if the treatment is working.
Ferritin antibody array kit
VArk-Lsx009 1 mg
EUR 419
Description: Used for detection of Ferritin
Microalbuminuria antibody array kit
VArk-Lsx010 1 mg
EUR 419
Description: Used to detect early signs of kidney damage
Pig Agouti signaling protein(ASIP) ELISA kit
E07A1721-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Agouti signaling protein(ASIP) ELISA kit
E07A1721-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Agouti signaling protein(ASIP) ELISA kit
E07A1721-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Notch-1 ELISA Kit| Mouse Neurogenic locus notch homolog protein
EF014010 96 Tests
EUR 689
Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)
T8234708-2 2 slides
EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)
T8234708-5 5 slides
EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
cDNA Synthesis SuperMix for qPCR
20-abx09801920ulSystems
  • EUR 690.00
  • EUR 565.00
  • 100 rxns ×20 ul Systems
  • 50 rxns × 20 ul Systems
  • Shipped within 5-10 working days.
HotTaq Probe qPCR Mix (ROX)
BT11001 250rxn
EUR 109
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.
HotTaq Probe qPCR Mix (Capillary)
BT11003 250rxn
EUR 109
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.
HotTaq Probe qPCR Universal Mix
BT11004 250rxn
EUR 123
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.
HotTaq EvaGreen qPCR Mix (ROX)
BT11101 250rxn
EUR 123
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.
HotTaq EvaGreen qPCR Mix (Capillary)
BT11103 250rxn
EUR 123
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.
HotTaq EvaGreen qPCR Universal Mix
BT11104 250rxn
EUR 138
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.
SYBR Green qPCR Master Mix
HY-K0501 5 mL (500 rxns)
EUR 263
RT Master Mix for qPCR
HY-K0510 1 mL (100 rxns)
EUR 291
Power Eva QPCR SuperMix Kit
K5057200 200 reactions
EUR 188
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.
Power Eva QPCR SuperMix Kit
K5057400 400 reactions
EUR 320
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.
Methylamp MS-qPCR Fast Kit
P-1028 200 Reactions
EUR 496.6
Description: fast delivery possible
BrightGreen 5X qPCR MasterMix-iCycler
MasterMix-5C 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213
TaqProbe 5X qPCR MasterMix-ROX
MasterMix-5P 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213
TaqProbe 5X qPCR MasterMix-iCycler
MasterMix-5PC 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213
TaqProbe 5X qPCR MasterMix-Multiplex
MasterMix-5PM 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213
BrightGreen 5X qPCR MasterMix-ROX
MasterMix-5R 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213
BrightGreen 2X qPCR MasterMix-iCycler
MasterMix-iC 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140
BrightGreen 2X qPCR MasterMix-iCycler
MasterMix-iC-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 376
KiloGreen 2X qPCR MasterMix-iCycler
MasterMix-KC 4 x 1.25 ml - 500 reactions (20 ul)
EUR 140
KiloGreen 2X qPCR MasterMix-ROX
MasterMix-KR 4 x 1.25 ml - 500 reactions (20 ul)
EUR 140
BrightGreen miRNA qPCR MasterMix-iCycler
MasterMix-mC 4 x 1.25 ml for 500 reactions
EUR 151
BrightGreen miRNA qPCR MasterMix-ROX
MasterMix-mR 4 x 1.25 ml for 500 reactions
EUR 151
TaqProbe 2X qPCR MasterMix-ROX
MasterMix-P 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140
TaqProbe 2X qPCR MasterMix-iCycler
MasterMix-PC 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140
TaqProbe 2X qPCR MasterMix-Multiplex
MasterMix-PM 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140
BrightGreen 2X qPCR MasterMix-ROX
MasterMix-R 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140
BrightGreen 2X qPCR MasterMix-ROX
MasterMix-R-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 376
AceQ qPCR Probe Master Mix
Q112-02 500 rxn (20 μl/rxn)
EUR 221
AceQ qPCR Probe Master Mix
Q112-03 2500 rxn (20 μl/rxn)
EUR 646
Notch 1 Blocking Peptide
33R-10562 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 20R-1749
Notch 1 Blocking Peptide
33R-10970 50 ug
EUR 191
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 70R-12158
Notch 1 Blocking Peptide
3881BP-50
EUR 153
Notch 3 antibody (PE)
61R-1343 100 ug
EUR 440
Description: Armenian Hamster monoclonal Notch3 antibody (PE)

Delta1 Notch ligand expression lines, Delta2 Jagged1, Jagged2 and receptor Notch1 and Notch2 in the RA group increases. Correlation analysis showed that HSA-miR155-3p is inversely proportional to MALAT1, HSA-miR155-3p is directly proportional to the Notch pathway Delta1, Jagged1, and MALAT1 is inversely proportional to Jagged2. Conclusions In patients with rheumatoid arthritis, lncRNA MALAT1 HSA-mir155-3p reduced and increased, which together regulate Notch signaling pathway changes.

Anthony

Related Posts

fallback-image

IMMUNOGLOBULINS

Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway

Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma

TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma

No Comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Tags

December 2021
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  

Recent Posts

Categories

Pages