Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Plastic changes in the anterior cingulate cortex (ACC) is very important in hypersensitivity to pain caused by peripheral nerve injury. The Notch signaling pathway has been shown to regulate differentiation and synaptic transmission. Therefore, this study was to investigate the function of Notch signaling pathway in the ACC during nociceptive transmission caused by neuropathy pain

.We adopt Western boltting, N- [N- (3,5-difluorophenacetyl) l-Alanyl] -S- Phenylglycine t-butyl ester (dAPT) microinjections, RNA interference targeting Notch1, hairy and enhancer of split (Hes) 1 or Hes5, electrophysiological recording and behavioral tests to verify the relationship between Notch signaling in the ACC and neuropathic pain in rats adult male Sprague Dawley .Levels of Notch intracellular domain (NICD) increased in the ACC at day 7 after chronic constriction injury (CCI) operation or spared nerve injury (SNI).

Meanwhile, the mRNA level of Notch signaling downstream effector Hes1 Hes5 mRNA increased while the rate unchanged. Injection of DAPT, a γ-Secretase (the key enzyme involved in the Notch pathway) inhibitors, ACC to significantly reversed neuropathic pain behavior. Intra-ACC injection of short hairpin RNA (shRNA) -Notch reduce the expression of NICD and lower potentiation of synaptic transmission in the ACC. In addition, the perception of pain is also addressed in mice undergoing CCI or SNI. This process is mainly mediated by Hes1 downstream effectors, but not Hes5.Based this result, activation of the Notch / Hes1 signaling pathway in the ACC participated in the development of neuropathic pain, suggesting that Notch pathway may be a new therapeutic target to treat chronic pain.

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain
Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

[Decrease in long chains MALAT1 non-coding RNA expression and increased expression of HSA-miR155-3p involved in the regulation of Notch signaling pathway in patients with rheumatoid arthritis]

Objective To investigate the expression of a long chain of non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and HSA-miR155-3p in patients with rheumatoid arthritis (RA) and their relationship with the Notch signaling pathway, and explore the possibility of RA pathogenesis. Method peripheral blood of patients with RA (RA group) and healthy controls (group NC) was used to screen differentially expressed mRNA by lncRNA and high-throughput gene sequencing.

Reverse-transcription PCR is used to detect the expression of lncRNA MALAT1, HSA-miR155-3p and Notch signaling pathway receptor ligands. Results lncRNA sequencing analysis showed a total of 9158 lncRNAs are expressed differently. Gene ontology (GO) annotation of functional classification revealed that differential mRNA is expressed mainly involved in inflammatory immune response, cellular transcriptional regulation and so on.

path analysis proves that the differentially expressed mRNA was significantly associated with genes involved in rheumatoid arthritis, cellular aging, and the Notch signaling pathway. According to the prediction of cis and trans, Jagged1-2, Delta1-2 and Notch1-2 probably closely related to RA. MALAT1 the RA group was lower than in group NC, and HSA-miR155-3p expression was significantly higher than in the NC group.

PLATEMAX ULTRA CLEAR PEELABLE HEAT SEALING FILM FOR QPCR. 100/500

HS-150-QPCR 100/pk
EUR 381.6
Description: Sealing Products; Sealing films - Axygen

LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles

RA910A-1 20 profiles
EUR 1329.6

Pig Notch Homolog 1 ELISA kit

E07N0594-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Notch Homolog 1 ELISA kit

E07N0594-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Notch Homolog 1 ELISA kit

E07N0594-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Array Designer

AD6 1
EUR 5097.6

Nylon Array

MVSNGA110 10 Slides
EUR 271.2

Nylon Array

MVSNGA120 20 Slides
EUR 435.6

Guinea pig Notch Homolog 1 ELISA kit

E05N0594-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Notch Homolog 1 ELISA kit

E05N0594-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Notch Homolog 1 ELISA kit

E05N0594-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Notch Homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

NOTCH Antibody

F53063-0.4ML 0.4 ml
EUR 379

QPCR Kit QPCR Mastermix DNA

MOL6354 EACH
EUR 231.42

Mouse Cell Array

17-701 1 pack
EUR 229.2
Description: Mouse cell lines (A-20, EL4, L1210, NIH/3T3, P815 and RAW 264.7)

Notch 1 antibody

70R-12158 100 ug
EUR 483.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 antibody

70R-31090 100 ug
EUR 392.4
Description: Rabbit polyclonal Notch 1 antibody

Notch 2 antibody

70R-31091 100 ug
EUR 392.4
Description: Rabbit polyclonal Notch 2 antibody

Notch 1 Antibody

3881-100
EUR 379.2

Notch 1 Antibody

3881-30T
EUR 175.2

Notch 1 Antibody

48766-100ul 100ul
EUR 399.6

Notch 1 Antibody

48766-50ul 50ul
EUR 286.8

Notch 1 antibody

10R-6539 50 ug
EUR 230.4
Description: Mouse monoclonal Notch 1 antibody

Notch 1 antibody

20R-1749 100 ug
EUR 807.6
Description: Rabbit polyclonal Notch 1 antibody

Notch 1 Antibody

abx139789-01mg 0.1 mg
EUR 427.2

pGreenFire1-Notch (plasmid)

TR020PA-1 10 ug
EUR 943.2

pGreenFire1-Notch (virus)

TR020VA-1 >2 x 10^6 IFUs
EUR 943.2

anti-Notch 2

YF-PA24259 50 ul
EUR 400.8
Description: Mouse polyclonal to Notch 2

Pig Agouti signaling protein(ASIP) ELISA kit

E07A1721-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Agouti signaling protein(ASIP) ELISA kit

E07A1721-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Agouti signaling protein(ASIP) ELISA kit

E07A1721-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Cell Array I

17-601 1 pack
EUR 229.2
Description: Human cell lines (HEK293, A-431, A549, Hela S3, Hep G2 and MCF7)

Human Cell Array II

17-602 1 pack
EUR 229.2
Description: Human cell lines (HL-60, Jurkat, K-562, MOLT-4, Raji and THP-1)

Amino Particle Array Kit

APAK-3567-7K 7X1 mL
EUR 669.6
Description: Amino Particle Array KitGentaur offers a wide variety of uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Fluorescent Particle Array Kit

FPAK-4058--10K 10 mL
EUR 675.6
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Blue Particle Array Kit

PAK-3567-7K 7X1 mL
EUR 675.6
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Blue Particle Array Kit

PAK-4067-8K 8X1 mL
EUR 675.6
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Blue Particle Array Kit

PAK-5067-10K 10X1 mL
EUR 1126.8
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Blue Particle Array Kit

PAK-5067-5A 5X1 mL
EUR 675.6
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Blue Particle Array Kit

PAK-5067-5B 5X1 mL
EUR 675.6
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Blue Particle Array Kit

PAK-7067-9K 9X1 mL
EUR 1126.8
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FDA Standard Tissue Array

T8234701-1 1 slides
EUR 256.8
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FDA Standard Tissue Array

T8234701-5 5 slides
EUR 784.8
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CA125 antibody array kit

VArk-Lsx008 1 mg
EUR 796.8
Description: CA125 can be used as a tumor marker to identify the type of tumor and check if the treatment is working.

Ferritin antibody array kit

VArk-Lsx009 1 mg
EUR 502.8
Description: Used for detection of Ferritin

Microalbuminuria antibody array kit

VArk-Lsx010 1 mg
EUR 502.8
Description: Used to detect early signs of kidney damage

Notch-1 ELISA Kit| Mouse Neurogenic locus notch homolog protein

EF014010 96 Tests
EUR 826.8

Notch 3 antibody (PE)

61R-1343 100 ug
EUR 528
Description: Armenian Hamster monoclonal Notch3 antibody (PE)

Notch 4 antibody (PE)

61R-1344 25 ug
EUR 249.6
Description: Armenian Hamster monoclonal Notch4 antibody (PE)

Notch 1 antibody (PE)

61R-1347 100 ug
EUR 424.8
Description: Mouse monoclonal Notch 1 antibody (PE)

Anti-NOTCH 2 Antibody

A00518 200uL
EUR 583.2
Description: Rabbit Polyclonal NOTCH 2 Antibody. Validated in IHC, WB and tested in Human.

Notch 1 Blocking Peptide

3881BP-50
EUR 183.6

Notch 1 Blocking Peptide

33R-10970 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 70R-12158

Notch 1 Blocking Peptide

33R-10562 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Notch 1 antibody, catalog no. 20R-1749

Notch 1 Antibody (APC)

abx139790-01mg 0.1 mg
EUR 510

Notch 1 Antibody (PE)

abx139791-01mg 0.1 mg
EUR 510

Anti-NOTCH 3 Antibody

A1653-100
EUR 444

Notch 3 (NOTCH3) Antibody

20-abx214675
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Notch 1 homolog antibody

70R-NR026 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 1 homolog antibody

Notch 2 homolog antibody

70R-NR027 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 2 homolog antibody

Notch 3 homolog antibody

70R-NR028 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 3 homolog antibody

Notch 4 homolog antibody

70R-NR029 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal Notch 4 homolog antibody

Notch-1, mouse recombinant

7530-25
EUR 366

Notch-2, mouse recombinant

7531-25
EUR 366

Anti-NOTCH 1 Antibody

A00033 200uL
EUR 573.6
Description: Rabbit Polyclonal NOTCH 1 Antibody. Validated in IHC, WB and tested in Human.

Polyclonal Notch 1 Antibody

AMM06725G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Notch 1 . This antibody is tested and proven to work in the following applications:

Notch 1 Conjugated Antibody

C48766 100ul
EUR 476.4

Guinea pig Agouti signaling protein(ASIP) ELISA kit

E05A1721-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Agouti signaling protein(ASIP) ELISA kit

E05A1721-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Agouti signaling protein(ASIP) ELISA kit

E05A1721-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 3 ELISA kit

E07S0137-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 3 ELISA kit

E07S0137-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 3 ELISA kit

E07S0137-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 1 ELISA kit

E07S0138-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 1 ELISA kit

E07S0138-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 1 ELISA kit

E07S0138-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Green qPCR SuperMix

20-abx098031
  • EUR 1245.60
  • EUR 526.80
  • EUR 760.80
  • 15 ml
  • 1 ml
  • 5 ml

Probe qPCR SuperMix

20-abx098040
  • EUR 1245.60
  • EUR 526.80
  • EUR 760.80
  • 15 ml
  • 1 ml
  • 5 ml

Universal qPCR Mixture

QPCR1000-UNIV 4X1.25ml
EUR 331.44

Mouse Notch-1(Neurogenic locus notch homolog protein 1) ELISA Kit

EM1527 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)

T8234708-2 2 slides
EUR 368.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)

T8234708-5 5 slides
EUR 694.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Carboxyl Blue Particle Array Kit

CPAK-10067--13K 13X1 mL
EUR 1138.8
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-3067--7K 7X1 mL
EUR 675.6
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-3567--4K 4X1 mL
EUR 420
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-3567--7K 7X1 mL
EUR 675.6
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-4067--8K 8X1 mL
EUR 675.6
Description: Carboxyl Blue Particle Array Kitare uniform particles, ranging in size from 0.05 um to 20 um, with surface functional groups such as carboxyl or amino groups for covalent coupling of proteins or other ligands.

Carboxyl Blue Particle Array Kit

CPAK-5067--10K 10 mL
EUR 1126.8
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Blue Particle Array Kit

CPAK-5067--5A 5X1 mL
EUR 675.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Blue Particle Array Kit

CPAK-5067--5B 5X1 mL
EUR 675.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Yellow Particle Array Kit

CPAK-7052--3K 3X1 mL
EUR 486
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Carboxyl Yellow Particle Array Kit

CPAK-7052--6K 6x1 mL
EUR 834
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Carboxyl Blue Particle Array Kit

CPAK-7067--9K 9X1 mL
EUR 1126.8
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Exo-Check Exosome Antibody Array

EXORAY200A-4 4 arrays
EUR 648

Exo-Check Exosome Antibody Array

EXORAY210A-8 8 arrays
EUR 1176

Glutathione Blue Particle Array Kit

GSHPAK--5067-4K 4X1 mL
EUR 949.2
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Streptavidin Blue Array Particle Kit

SVPAK-5067--10K 10 mL
EUR 1192.8
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Streptavidin Blue Array Particle Kit

SVPAK-5067--5A 5X1 mL
EUR 705.6
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Streptavidin Blue Array Particle Kit

SVPAK-5067--5B 5X1 mL
EUR 705.6
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UV Carboxyl Particle Array Kit

UVCPAK--5042-14K 14X1 mL
EUR 1533.6
Description: UltraRainbow Fluorescent Particlesare calibration particles that help you to determine if a flow cytometer is properly aligned and has a clean flow cell with no fluidic blockage. Using SPHERO? Alignment Particles, the coefficients of variation (CVs), peak channels, and histogram distributions can be measured to determine the alignment and functionality of the flow cytometer.

HIV-P24 antigen array kit

VArk-Lsx001 unit Ask for price
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood.

HCV core antigen array kit

VArk-Lsx002 unit Ask for price
Description: Measure the HCV core protein.

Procalcitonin (PCT) Antigen array kit

VArk-Lsx004 1 mg
EUR 973.2
Description: Used as an early and highly accurate biomarker for sepsis and infection.

NT-pro BNP array kit

VArk-Lsx007 1 mg
EUR 1786.8
Description: To help detect, diagnose, and evaluate the severity of congestive heart failure (CHF)

Exo-Check Exosome Antibody Array

322-EXO-FBS-50A-1 100 µg
EUR 469.2

Pig Suppressor of cytokine signaling 2 (SOCS2) ELISA Kit

abx516783-96tests 96 tests
EUR 1093.2

Guinea pig Suppressors Of Cytokine Signaling 3 ELISA kit

E05S0137-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 3 ELISA kit

E05S0137-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 3 ELISA kit

E05S0137-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 1 ELISA kit

E05S0138-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 1 ELISA kit

E05S0138-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 1 ELISA kit

E05S0138-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig WNT1 Inducible Signaling Pathway Protein 1 ELISA kit

E07W0001-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine WNT1 Inducible Signaling Pathway Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig WNT1 Inducible Signaling Pathway Protein 1 ELISA kit

E07W0001-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine WNT1 Inducible Signaling Pathway Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig WNT1 Inducible Signaling Pathway Protein 1 ELISA kit

E07W0001-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine WNT1 Inducible Signaling Pathway Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator Of G Protein Signaling 4 ELISA kit

E07R0039-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator Of G Protein Signaling 4 ELISA kit

E07R0039-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator Of G Protein Signaling 4 ELISA kit

E07R0039-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Notch Homolog 4 (NOTCH4) Antibody

20-abx130314
  • EUR 577.20
  • EUR 159.60
  • EUR 1696.80
  • EUR 794.40
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Notch Homolog 3 (NOTCH3) Antibody

20-abx128882
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Notch Homolog 2 (NOTCH2) Antibody

20-abx128883
  • EUR 543.60
  • EUR 159.60
  • EUR 1579.20
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Notch Homolog 4 (NOTCH4) Antibody

20-abx128884
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Notch Homolog 3 (Drosophila) Antibody

20-abx114156
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Notch 1 (Cleaved-Val1754) Antibody

20-abx015544
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Notch 2 (Cleaved-Asp1733) Antibody

20-abx015545
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Notch 2 (Cleaved- Asp1733) Antibody

ABF5296 100 ug
EUR 525.6

Notch 1 (Cleaved- Val1744) Antibody

ABF5307 100 ug
EUR 525.6

Notch Homolog 4 (NOTCH4) Antibody

20-abx210338
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Notch Homolog 4 (NOTCH4) Antibody

20-abx210428
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Notch Homolog 2 (NOTCH2) Antibody

20-abx334061
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Notch 1 (Cleaved-Val1744) Antibody

abx217212-100ug 100 ug
EUR 526.8

Notch Homolog 4 (NOTCH4) Antibody

20-abx325047
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Notch Homolog 2 (NOTCH2) Antibody

20-abx328870
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Notch Homolog 2 (NOTCH2) Antibody

20-abx327263
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Notch Homolog 2 (NOTCH2) Antibody

20-abx327264
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Notch Homolog 2 (NOTCH2) Antibody

20-abx213982
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Notch Homolog 2 (NOTCH2) Antibody

20-abx173849
  • EUR 1111.20
  • EUR 560.40
  • 1 mg
  • 200 ug

Notch Homolog 2 (NOTCH2) Antibody

20-abx241404
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Cleaved-Notch 1 (Val1744) Antibody

AF5307 200ul
EUR 420

Notch-1 (human) ELISA Kit

K4763-100 100 assays
EUR 970.8
Description: Sensitive, Colorimetric Assay

Recombinant Notch Homolog 3 (NOTCH3)

4-RPL147Hu01
  • EUR 569.44
  • EUR 276.00
  • EUR 1805.38
  • EUR 681.79
  • EUR 1243.58
  • EUR 456.00
  • EUR 4333.44
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Notch Homolog 3 expressed in: E.coli

Recombinant Notch Homolog 2 (NOTCH2)

4-RPL148Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Notch Homolog 2 expressed in: E.coli

Recombinant Notch Homolog 4 (NOTCH4)

4-RPL149Hu01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Notch Homolog 4 expressed in: E.coli

Recombinant Notch Homolog 4 (NOTCH4)

4-RPL149Ra01
  • EUR 633.95
  • EUR 292.80
  • EUR 2047.30
  • EUR 762.43
  • EUR 1404.86
  • EUR 499.20
  • EUR 4938.24
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Notch Homolog 4 expressed in: E.coli

pGreenFire1-Notch (plasmid)+ EF1-Neo

TR020PA-N 10 ug
EUR 943.2

pGreenFire1-Notch (plasmid)+ EF1-Puro

TR020PA-P 10 ug
EUR 943.2

pGreenFire1-Notch (virus) + EF1-Neo

TR020VA-N >2 x 10^6 IFUs
EUR 943.2

pGreenFire1-Notch (virus) + EF1-Puro

TR020VA-P >2 x 10^6 IFUs
EUR 943.2

Green qPCR SuperMix UDG

20-abx098032
  • EUR 1362.00
  • EUR 543.60
  • EUR 794.40
  • 15 ml
  • 1 ml
  • 5 ml

Top Green qPCR SuperMix

20-abx098033
  • EUR 994.80
  • EUR 260.40
  • EUR 1362.00
  • EUR 493.20
  • 15 ml
  • 1 ml
  • 25 ml
  • 5 ml

Tip Green qPCR SuperMix

20-abx098034
  • EUR 1161.60
  • EUR 276.00
  • EUR 1596.00
  • EUR 560.40
  • 15 ml
  • 1 ml
  • 25 ml
  • 5 ml

Library Quantification qPCR SuperMix

20-abx098896
  • EUR 276.00
  • EUR 493.20
  • 1 ml
  • 5 ml

QPCR Positive Control Kit

M1126-100
EUR 483.6

Delta1 Notch ligand expression lines, Delta2 Jagged1, Jagged2 and receptor Notch1 and Notch2 in the RA group increases. Correlation analysis showed that HSA-miR155-3p is inversely proportional to MALAT1, HSA-miR155-3p is directly proportional to the Notch pathway Delta1, Jagged1, and MALAT1 is inversely proportional to Jagged2. Conclusions In patients with rheumatoid arthritis, lncRNA MALAT1 HSA-mir155-3p reduced and increased, which together regulate Notch signaling pathway changes.

Anthony

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