Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Plastic changes in the anterior cingulate cortex (ACC) is very important in hypersensitivity to pain caused by peripheral nerve injury. The Notch signaling pathway has been shown to regulate differentiation and synaptic transmission. Therefore, this study was to investigate the function of Notch signaling pathway in the ACC during nociceptive transmission caused by neuropathy pain

.We adopt Western boltting, N- [N- (3,5-difluorophenacetyl) l-Alanyl] -S- Phenylglycine t-butyl ester (dAPT) microinjections, RNA interference targeting Notch1, hairy and enhancer of split (Hes) 1 or Hes5, electrophysiological recording and behavioral tests to verify the relationship between Notch signaling in the ACC and neuropathic pain in rats adult male Sprague Dawley .Levels of Notch intracellular domain (NICD) increased in the ACC at day 7 after chronic constriction injury (CCI) operation or spared nerve injury (SNI).

Meanwhile, the mRNA level of Notch signaling downstream effector Hes1 Hes5 mRNA increased while the rate unchanged. Injection of DAPT, a γ-Secretase (the key enzyme involved in the Notch pathway) inhibitors, ACC to significantly reversed neuropathic pain behavior. Intra-ACC injection of short hairpin RNA (shRNA) -Notch reduce the expression of NICD and lower potentiation of synaptic transmission in the ACC. In addition, the perception of pain is also addressed in mice undergoing CCI or SNI. This process is mainly mediated by Hes1 downstream effectors, but not Hes5.Based this result, activation of the Notch / Hes1 signaling pathway in the ACC participated in the development of neuropathic pain, suggesting that Notch pathway may be a new therapeutic target to treat chronic pain.

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain
Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

[Decrease in long chains MALAT1 non-coding RNA expression and increased expression of HSA-miR155-3p involved in the regulation of Notch signaling pathway in patients with rheumatoid arthritis]

Objective To investigate the expression of a long chain of non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and HSA-miR155-3p in patients with rheumatoid arthritis (RA) and their relationship with the Notch signaling pathway, and explore the possibility of RA pathogenesis. Method peripheral blood of patients with RA (RA group) and healthy controls (group NC) was used to screen differentially expressed mRNA by lncRNA and high-throughput gene sequencing.

Reverse-transcription PCR is used to detect the expression of lncRNA MALAT1, HSA-miR155-3p and Notch signaling pathway receptor ligands. Results lncRNA sequencing analysis showed a total of 9158 lncRNAs are expressed differently. Gene ontology (GO) annotation of functional classification revealed that differential mRNA is expressed mainly involved in inflammatory immune response, cellular transcriptional regulation and so on.

path analysis proves that the differentially expressed mRNA was significantly associated with genes involved in rheumatoid arthritis, cellular aging, and the Notch signaling pathway. According to the prediction of cis and trans, Jagged1-2, Delta1-2 and Notch1-2 probably closely related to RA. MALAT1 the RA group was lower than in group NC, and HSA-miR155-3p expression was significantly higher than in the NC group.

Pig Agouti signaling protein(ASIP) ELISA kit

E07A1721-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Agouti signaling protein(ASIP) ELISA kit

E07A1721-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Agouti signaling protein(ASIP) ELISA kit

E07A1721-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles

RA900A-1 20 profiles
EUR 1020

Mouse LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles

RA930A-1 20 profiles
EUR 1020

Guinea pig Agouti signaling protein(ASIP) ELISA kit

E05A1721-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Agouti signaling protein(ASIP) ELISA kit

E05A1721-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Agouti signaling protein(ASIP) ELISA kit

E05A1721-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 3 ELISA kit

E07S0137-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 3 ELISA kit

E07S0137-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 3 ELISA kit

E07S0137-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 1 ELISA kit

E07S0138-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 1 ELISA kit

E07S0138-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressors Of Cytokine Signaling 1 ELISA kit

E07S0138-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator Of G Protein Signaling 4 ELISA kit

E07R0039-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator Of G Protein Signaling 4 ELISA kit

E07R0039-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator Of G Protein Signaling 4 ELISA kit

E07R0039-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Suppressor of cytokine signaling 2 (SOCS2) ELISA Kit

abx516783-96tests 96 tests
EUR 1093.2

Pig Regulator of G Protein Signaling 4 (RGS4) ELISA Kit

abx360740-96tests 96 tests
EUR 990

Pig Regulator of G protein signaling 17(RGS17) ELISA kit

E07R0408-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Regulator of G protein signaling 17(RGS17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator of G protein signaling 17(RGS17) ELISA kit

E07R0408-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Regulator of G protein signaling 17(RGS17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator of G protein signaling 17(RGS17) ELISA kit

E07R0408-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Regulator of G protein signaling 17(RGS17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator of G protein signaling 20(RGS20) ELISA kit

E07R0409-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Regulator of G protein signaling 20(RGS20) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator of G protein signaling 20(RGS20) ELISA kit

E07R0409-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Regulator of G protein signaling 20(RGS20) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator of G protein signaling 20(RGS20) ELISA kit

E07R0409-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Regulator of G protein signaling 20(RGS20) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 3 ELISA kit

E05S0137-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 3 ELISA kit

E05S0137-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 3 ELISA kit

E05S0137-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 1 ELISA kit

E05S0138-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 1 ELISA kit

E05S0138-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Suppressors Of Cytokine Signaling 1 ELISA kit

E05S0138-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig WNT1 Inducible Signaling Pathway Protein 1 ELISA kit

E07W0001-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine WNT1 Inducible Signaling Pathway Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig WNT1 Inducible Signaling Pathway Protein 1 ELISA kit

E07W0001-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine WNT1 Inducible Signaling Pathway Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig WNT1 Inducible Signaling Pathway Protein 1 ELISA kit

E07W0001-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine WNT1 Inducible Signaling Pathway Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator Of G Protein Signaling 4 ELISA kit

E05R0039-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator Of G Protein Signaling 4 ELISA kit

E05R0039-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator Of G Protein Signaling 4 ELISA kit

E05R0039-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

DAP10 Signaling Fragment

5-01031 4 x 1mg Ask for price

LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles

RA910A-1 20 profiles
EUR 1329.6

Guinea pig Regulator of G Protein Signaling 4 (RGS4) ELISA Kit

abx357487-96tests 96 tests
EUR 990

Guinea pig Suppressors of Cytokine Signaling 3 (SOCS3) ELISA Kit

abx357380-96tests 96 tests
EUR 990

Guinea pig Regulator of G protein signaling 17(RGS17) ELISA kit

E05R0408-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator of G protein signaling 17(RGS17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator of G protein signaling 17(RGS17) ELISA kit

E05R0408-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator of G protein signaling 17(RGS17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator of G protein signaling 17(RGS17) ELISA kit

E05R0408-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator of G protein signaling 17(RGS17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator of G protein signaling 20(RGS20) ELISA kit

E05R0409-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator of G protein signaling 20(RGS20) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator of G protein signaling 20(RGS20) ELISA kit

E05R0409-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator of G protein signaling 20(RGS20) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator of G protein signaling 20(RGS20) ELISA kit

E05R0409-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator of G protein signaling 20(RGS20) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig WNT1 Inducible Signaling Pathway Protein 1 ELISA kit

E05W0001-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig WNT1 Inducible Signaling Pathway Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig WNT1 Inducible Signaling Pathway Protein 1 ELISA kit

E05W0001-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig WNT1 Inducible Signaling Pathway Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig WNT1 Inducible Signaling Pathway Protein 1 ELISA kit

E05W0001-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig WNT1 Inducible Signaling Pathway Protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Statin Signaling Library

HSTAT-I 1 set
EUR 657.6

Hh Signaling Pathway Antagonist

1659-1 each
EUR 216

Rat Bdnf Signaling Primer Library

RBDNF-I 1 set
EUR 774

Rat Gdnf Signaling Primer Library

RGDNF-I 1 set
EUR 774

Mouse Ras Signaling Primer Library

MRAS-I 1 set
EUR 657.6

Mouse p53 Signaling Primer Library

MTPS-I 1 set
EUR 540

Mouse WNT Signaling Primer Library

MWNT-I 1 set
EUR 657.6

Mouse BMP Signaling Primer Library

MBMP-I 1 set
EUR 657.6

ER Signaling Protein Detection Set

PSI-1814 1 Set
EUR 752.1
Description: The endoplasmic reticulum (ER) is an organelle composed of an interconnected network of tubules, vesicles and cisternae found in all eukaryotic cells. It is involved in several specialized processes such as protein translation, folding, and transport of proteins to be used in the cell membrane or secreted from the cell. Accumulation of malfolded proteins in the ER activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase, to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA, converting it to a potent UPR transcriptional activator. ER stress also causes the cleavage of ATF6, yielding a cytosolic fragment which migrates to the nucleus and together with XBP-1, activates transcription of UPR-responsive genes. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.;;For images please see PDF data sheet

Human BMP Signaling Primer Library

HBMP-I 1 set
EUR 657.6

Human MAP Kinase Signaling Library

HMAP-I 1 set
EUR 657.6

Human Ras Signaling Primer Library

HRAS-I 1 set
EUR 657.6

Human TNF Signaling Primer Library

HTNF-I 1 set
EUR 657.6

Human p53 Signaling Primer Library

HTPS-I 1 set
EUR 540

Human WNT Signaling Primer Library

HWNT-I 1 set
EUR 657.6

Mouse Gdnf Signaling Primer Library

MGDNF-I 1 set
EUR 657.6

Mouse Bdnf Signaling Primer Library

MBDNF-I 1 set
EUR 657.6

Mouse CREB Signaling Primer Library

MCREB-I 1 set
EUR 657.6

Mouse EGFR Signaling Primer Library

MEGFR-I 1 set
EUR 657.6

TOR Signaling Pathway Detection Set

PSI-1805 1 Set
EUR 1287.6
Description: The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle progression through its ability to integrate signals from nutrient levels and growth factors. TOR regulation is accomplished through a network of various activators and repressors. It is phosphorylated by Akt, whose activity is indirectly inhibited by the lipid phosphatase PTEN. TOR is normally associated with the regulatory proteins RAPTOR, a scaffold protein whose binding by TOR substrates is necessary for effective TOR-catalyzed phosphorylation, and GΒL, which stimulates TOR’s kinase activity towards downstream proteins. It is further regulated by the proteins Rheb, TSC1 and TSC2, which act to modulate TOR activity. The downstream targets of TOR are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs) whose activation leads to increased protein translation and cell growth.;;For images please see PDF data sheet

Human EGFR Signaling Primer Library

HEGFR-I 1 set
EUR 657.6

Human ERBB Signaling Primer Library

HERBB-I 1 set
EUR 657.6

Human GDNF Signaling Primer Library

HGDNF-I 1 set
EUR 657.6

Human IL17 Signaling Primer Library

HIL17-I 1 set
EUR 657.6

Human BDNF Signaling Primer Library

HBDNF-I 1 set
EUR 657.6

Human cAMP Signaling Primer Library

HCAMP-I 1 set
EUR 657.6

Human CREB Signaling Primer Library

HCREB-I 1 set
EUR 657.6

Human PDGF Signaling Primer Library

HPDGF-I 1 set
EUR 657.6

Human SMAD Signaling Primer Library

HSMAD-I 1 set
EUR 657.6

Human VEGF Signaling Primer Library

HVEGF-I 1 set
EUR 657.6

Mouse Hippo Signaling Primer Library

MHPO-I 1 set
EUR 657.6

Human Hippo Signaling Primer Pathway

HHPO-I 1 set
EUR 657.6

Cyclopamine (Hedgehog signaling blocker)

SIH-226-1MG 1 mg
EUR 162
Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol.

Cyclopamine (Hedgehog signaling blocker)

SIH-226-5MG 5 mg
EUR 414
Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol.

Pig Regulator of G protein signaling 9 binding protein(RGS9BP) ELISA kit

E07R0410-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Regulator of G protein signaling 9 binding protein(RGS9BP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator of G protein signaling 9 binding protein(RGS9BP) ELISA kit

E07R0410-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Regulator of G protein signaling 9 binding protein(RGS9BP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Regulator of G protein signaling 9 binding protein(RGS9BP) ELISA kit

E07R0410-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Regulator of G protein signaling 9 binding protein(RGS9BP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Integrin Signaling Primer Library

RINT-I 1 set
EUR 1008

Agouti Signaling Protein (ASIP) Antibody

abx122198-100ug 100 ug
EUR 469.2

Agouti Signaling Protein (ASIP) Antibody

20-abx148376
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Agouti Signaling Protein (ASIP) Antibody

20-abx005235
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Mouse Hypoxia Signaling Primer Library

MHYP-I 1 set
EUR 657.6

DiscoveryProbe? NF-?B Signaling Library

L1044-.1 100 uL/well(10 mM solution)
EUR 1730.4

DiscoveryProbe? NF-?B Signaling Library

L1044-.25 250 uL/well(10 mM solution)
EUR 3052.8

DiscoveryProbe? NF-?B Signaling Library

L1044-5 5 mg/well
EUR 3970.8

Human Hypoxia Signaling Primer Library

HHYP-I 1 set
EUR 657.6

Human Insulin Signaling Primer Library

HINS-I 1 set
EUR 657.6

DiscoveryProbe? Neuronal Signaling Library

L1026-.1 100 uL/well(10 mM solution)
EUR 5961.6

DiscoveryProbe? Neuronal Signaling Library

L1026-.25 250 uL/well(10 mM solution)
EUR 10639.2

DiscoveryProbe? Neuronal Signaling Library

L1026-5 5 mg/well
EUR 13840.8

Mouse Integrin Signaling Primer Library

MINT-I 1 set
EUR 891.6

Human Estrogen Signaling Primer Library

HESR-I 1 set
EUR 774

Human Hedgehog Signaling Primer Library

HHOG-I 1 set
EUR 774

Human Integrin Signaling Primer Library

HINT-I 1 set
EUR 657.6

Human Androgen Signaling Primer Library

HAND-I 1 set
EUR 657.6

Myc Reporter Kit (Myc Signaling Pathway)

60519 500 rxns.
EUR 625
Description: The Myc Pathway Reporter kit is designed for monitoring the activity of the Myc signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for c- Myc and Myc luciferase reporter vector. Inside the cells, c-Myc will bind to Max, translocate to the nucleus, and induce expression of the Myc luciferase reporter vector. This reporter contains the firefly luciferase gene under the control of multimerized Myc responsive elements located upstream of a minimal promoter. The Myc reporter is premixed with constitutively-expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutivelyexpressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway-specific effects and background luciferase activity.

Mouse TGF Beta Signaling Primer Library

MTGFB-I 1 set
EUR 657.6

Mouse Jak/Stat Signaling Primer Library

MJAK-I 1 set
EUR 774

Human JAK/STAT Signaling Primer Library

HJAK-I 1 set
EUR 657.6

Human TGF Beta Signaling Primer Library

HTGFB-I 1 set
EUR 657.6

Mouse Estrogen Receptor Signaling Library

MESR-I 1 set
EUR 774

Canopy FGF Signaling Regulator 1 Protein

20-abx262747
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Canopy FGF Signaling Regulator 4 Protein

20-abx263419
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Mouse PI3K-AKT Signaling Primer Library

MAKT-I 1 set
EUR 657.6

Mouse DNA Damage Signaling Primer Library

MDDS-I 1 set
EUR 657.6

Mouse MAP Kinase Signaling Primer Library

MMAP-I 1 set
EUR 657.6

Human PI3K-AKT Signaling Primer Library

HAKT-I 1 set
EUR 540

PathwayReady? EGFR Signaling Inhibitor Panel

K863-14 each
EUR 1488

Guinea pig Regulator of G protein signaling 9 binding protein(RGS9BP) ELISA kit

E05R0410-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator of G protein signaling 9 binding protein(RGS9BP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator of G protein signaling 9 binding protein(RGS9BP) ELISA kit

E05R0410-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator of G protein signaling 9 binding protein(RGS9BP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Regulator of G protein signaling 9 binding protein(RGS9BP) ELISA kit

E05R0410-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Regulator of G protein signaling 9 binding protein(RGS9BP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

STAT3 Reporter Kit (STAT3 Signaling Pathway)

79730 500 rxns.
EUR 640
Description: The STAT3 Reporter kit is designed for monitoring the activity of the STAT3 signaling pathway in cultured cells. The kit contains transfection-ready STAT3 luciferase reporter vector. This reporter contains a firefly luciferase gene under the control of STAT3-responsive element located upstream of a minimal promoter. The STAT3 reporter is premixed with constitutively expressing Renilla luciferase vector, which serves as an internal control for transfection efficiency._x000D_
The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway-specific effects and background luciferase activity.

Mouse Fatty Liver Signaling Primer Library

MFTL-I 1 set
EUR 657.6

TCF/LEF Reporter Kit (Wnt Signaling Pathway)

60500 500 rxns.
EUR 655
Description: The TCF/LEF Reporter kit is designed for monitoring the activity of Wnt / β-catenin signaling pathway in the cultured cells. The kit contains transfection-ready TCF/LEF luciferase reporter vector, which is a Wnt pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized TCF/LEF responsive element located upstream of a minimal promoter. The TCF/LEF reporter is premixed with constitutively-expressing Renilla luciferase vector that serves as internal control for transfection efficiency. _x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway specific effects and background luciferase activity. _x000D_

Suppressor Of Cytokine Signaling 3 Protein

20-abx262753
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Human FGF Receptor Signaling Primer Library

HFGF-I 1 set
EUR 774

Human Nitric Oxide Signaling Primer Library

HNOS-I 1 set
EUR 657.6

Rat Neurotransmitter Signaling Primer Library

RNTS-I 1 set
EUR 774

Rat Agouti Signaling Protein (ASIP) ELISA Kit

abx390953-96tests 96 tests
EUR 1093.2

SRE Reporter Kit (MAPK/ERK Signaling Pathway )

60511 500 rxns.
EUR 595
Description: The SRE Reporter Kit is designed for monitoring the activity of the ERK signaling pathway and the transcriptional activity of SRF in cultured cells. The kit contains a transfection-ready SRE luciferase reporter vector, which is an ERK pathway-responsive reporter. This reporter contains the firefly luciferase gene under the control of multimerized SRE responsive elements located upstream of a minimal promoter. The SRE reporter is premixed with a constitutively-expressing Renilla (sea pansy) luciferase vector that serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical for determining pathway-specific effects and the background luciferase activity.

Dog Agouti signaling protein(ASIP) ELISA kit

E08A1721-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Agouti signaling protein(ASIP) ELISA kit

E08A1721-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Agouti signaling protein(ASIP) ELISA kit

E08A1721-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Agouti signaling protein(ASIP) ELISA kit

E02A1721-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Agouti signaling protein(ASIP) ELISA kit

E02A1721-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Agouti signaling protein(ASIP) ELISA kit

E02A1721-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Breast Cancer Signaling Primer Library

HBRCA-I 1 set
EUR 657.6

ISRE Reporter Kit (JAK/STAT Signaling Pathway)

60613 500 rxns.
EUR 565
Description: The ISRE Reporter kit is designed for monitoring the activity of Type I interferon-induced JAK/STAT signaling pathway in the cultured cells. The kit contains transfection-ready ISRE luciferase reporter vector, which is a JAK/STAT pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized ISRE responsive element located upstream of a minimal promoter. The ISRE reporter is premixed with constitutively-expressing Renilla (sea pansy) luciferase vector, which serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The noninducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway specific effects and background luciferase activity.

SBE Reporter Kit (TGFβ/SMAD signaling pathway)

60654 500 rxns.
EUR 595
Description: The SBE Reporter kit is designed for monitoring the activity of TGFβ/SMAD signaling pathway in the cultured cells. The kit contains transfection-ready SBE luciferase reporter vector, which is a TGFβ pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized SBE responsive element located upstream of a minimal promoter. The SBE reporter is premixed with constitutively-expressing Renilla luciferase vector that serves as internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as negative control. The noninducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway-specific effects and background luciferase activity.

Goat Agouti signaling protein(ASIP) ELISA kit

E06A1721-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Agouti signaling protein(ASIP) ELISA kit

E06A1721-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Agouti signaling protein(ASIP) ELISA kit

E06A1721-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Virus Induced Signaling Adapter (VISA) Antibody

20-abx175096
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

Virus Induced Signaling Adapter (VISA) Antibody

20-abx178881
  • EUR 1446.00
  • EUR 693.60
  • 1 mg
  • 200 ug

Human Focal Adhesion Signaling Primer Library

HFCA-I 1 set
EUR 657.6

Mouse Neurotransmitter Signaling Primer Library

MNTS-I 1 set
EUR 657.6

Human Neurotransmitter Signaling Primer Library

HNTS-I 1 set
EUR 657.6

Regulator of G-Protein Signaling 19 Protein

20-abx260826
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Regulator of G-Protein Signaling 10 Protein

20-abx261468
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Regulator of G-Protein Signaling 21 Protein

20-abx261473
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Regulator of G-Protein Signaling 17 Protein

20-abx261493
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Regulator of G-Protein Signaling 16 Protein

20-abx262881
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Delta1 Notch ligand expression lines, Delta2 Jagged1, Jagged2 and receptor Notch1 and Notch2 in the RA group increases. Correlation analysis showed that HSA-miR155-3p is inversely proportional to MALAT1, HSA-miR155-3p is directly proportional to the Notch pathway Delta1, Jagged1, and MALAT1 is inversely proportional to Jagged2. Conclusions In patients with rheumatoid arthritis, lncRNA MALAT1 HSA-mir155-3p reduced and increased, which together regulate Notch signaling pathway changes.

Anthony

Related Posts

fallback-image

IMMUNOGLOBULINS

Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway

Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma

TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma

No Comment

Leave a Reply

Your email address will not be published.

Tags

November 2023
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
27282930  

Recent Posts

Categories

Pages