Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

Background: Recently, Notch signaling pathway has gained attention as a potential therapeutic target for chemotherapeutic intervention. However, the efficacy of previously known inhibitors of Notch in colon cancer remains unclear. The purpose of this study was to determine the effect of andrographolide in aberrantly activated Notch signaling in SW-480 cells in vitro.


Methods: The potential cytostatic andrografolida on SW-480 cells was evaluated by 3- (4,5-dimethylthiazol-2-yl) -2, 5-diphenyl tetrazolium bromide (MTT) assay, assessment of morphology and colony formation test. FITC apoptosis activity was evaluated by Annexin V assay, 4 ‘, 6-diamidino-2-phenylindole (DAPI), Hoechst, Rhodamine 123 and Mito Tracker staining CMXRos. Scratching assay for assessment of potential migration. 7’-Dichlorodihydrofluorescein Diacetate (DCFH-DA) staining was used to evaluate Reactive Oxygen Species (ROS) generation. mRNA relative expression of Bax, Bcl-2, NOTCH 1 and jagged 1 was estimated by real-time quantitative reverse transcription PCR (qRT-PCR). cell cycle phase distribution was evaluated Annexin V-FITC / PI staining.


Results: MTT assay showed a dose and time dependent cytoxicity of andrographolide on SW-480 cells. It also inhibits migratory and colony forming potential of SW-480 cells. In addition, andrografolida also showed impaired mitochondrial membrane potential and induced apoptosis through nuclear condensation. Flow cytometric evaluation showed improved early and late andrographolide cells induced apoptosis and upregulation of proapoptotic (Bax and Bad) and downregulation of Bcl-2 antiapoptotic in SW-480 treated cells. Andrographolide plus intracellular ROS and induced G0 / G1 phase cell cycle arrest in SW480 colon cancer cells. Furthermore, andrografolida suppress Notch signaling by reducing the expression of NOTCH 1 and jagged one.
Conclusions: Our findings indicate that the andrographolide constraints SW-480 cell growth through inhibition of the Notch signaling pathway.

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway
Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

MicroRNA-133b exacerbate atherosclerosis by activating the Notch signaling pathway1

The purpose of this study was to determine the effect of miR-133b in atherosclerosis (AS). A rat model of AS (AS Group) was established, and serum levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein (LDL) cholesterol were detected. The thoracic aorta tissue was subjected to hematoxylin and eosin staining for pathological examination. Mice were intravenously injected with microRNA (mir) -133b mimic (group miR-133b mimic + US) and miR-133b mimic negative control (miR-133b group NC + US).

Normal mice given the name of Sham group. reconstruction parameters of vascular, inflammatory factors Ratio Collagen / Vascular Area (CA / CVA) and serum of mice in each group were detected. MRNA expression was measured by quantitative reverse transcription-PCR and protein expression was determined by western blot analysis. An in vitro model of the US induced in vascular smooth muscle cells (VSMC) using oxidized (ox) -LDL. CCK-8 and wound healing tests used to detect cell proliferation and migration.

Compared with Sham group, the rats of the US group, AS + miR-133b mimic NC group and the group AS + miR-133b have a higher intima thickness (IT), tumor necrosis factor (TNF) -α and monocytes kemoatraktan protein (MCP) -1 level, as well as increased expression of Notch1 and Jagged1; and they have a lower medial thickness (MT), the ratio CA / CVA and Notch3 expression (all P <0.05).

CF568 donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20105
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20106
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 rabbit anti-goat IgG(H+L)

9-20107
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 goat anti-guinea pig IgG(H+L)

9-20108
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-mouse IgG(H+L)

9-20110
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20111
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-rabbit IgG(H+L)

9-20112
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20113
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20114
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20115
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20116
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-goat IgG(H+L)

9-20117
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-guinea pig IgG(H+L)

9-20118
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-mouse IgG(H+L)

9-20120
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20121
  • EUR 319.20
  • EUR 326.40
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-rabbit IgG(H+L)

9-20122
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20123
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20124
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20125
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20126
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20127
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 rabbit anti-goat IgG(H+L)

9-20128
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-guinea pig IgG(H+L)

9-20129
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-human IgG(H+L), highly cross-adsorbed

9-20132
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20133
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20134
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 rabbit anti-rat IgG(H+L), highly cross-adsorbed

9-20135
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20136
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-rat IgG(H+L), highly cross-adsorbed

9-20137
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-swine IgG(H+L)

9-20138
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-mouse IgG(H+L)

9-20140
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-rabbit IgG(H+L)

9-20141
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20142
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20143
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20144
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20147
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20148
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20149
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20152
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-human IgG(H+L), highly cross-adsorbed

9-20154
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20155
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20156
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-rat IgG(H+L), highly cross-adsorbed

9-20157
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20158
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-rat IgG(H+L), highly cross-adsorbed

9-20159
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-swine IgG(H+L)

9-20160
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-chicken IgY ( IgG) (H+L)

9-20164
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 rabbit anti-chicken IgY (IgG) (H+L)

9-20165
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20166
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20167
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20168
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A donkey anti-guinea pig IgG(H+L), highly cross-adsorbed

9-20169
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-guinea pig IgG(H+L), highly cross-adsorbed

9-20170
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-guinea pig IgG(H+L), highly cross-adsorbed

9-20171
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A rabbit anti-sheep IgG(H+L), highly cross-adsorbed

9-20172
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-sheep IgG(H+L), highly cross-adsorbed

9-20173
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-sheep IgG(H+L), highly cross-adsorbed

9-20174
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20175
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20176
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20177
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20178
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20179
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF405M goat anti-mouse IgG(H+L)

9-20180
  • EUR 271.20
  • EUR 277.20
  • 0.5 mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF405M goat anti-rabbit IgG(H+L)

9-20181
  • EUR 271.20
  • EUR 277.20
  • 0.5 mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF405M goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20182
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin goat anti-mouse IgG(H+L)

9-20183
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20184
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin goat anti-rabbit IgG(H+L)

9-20185
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20186
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20189
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20190
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20191
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R goat anti-mouse IgG(H+L)

9-20197
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-guinea pig IgG(H+L)

9-20198
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R donkey anti-rat IgG(H+L), highly cross-adsorbed

9-20199
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R rabbit anti-mouseIgG(H+L), highly cross-adsorbed

9-20200
  • EUR 283.20
  • EUR 290.40
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R rabbit anti-rat IgG(H+L), highly cross-adsorbed

9-20201
  • EUR 283.20
  • EUR 290.40
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R goat anti-rabbit IgG(H+L)

9-20202
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A chicken anti-mouse IgG(H+L)

9-20208
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A chicken anti-rabbit IgG(H+L)

9-20209
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 chicken anti-mouse IgG(H+L)

9-20221
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 chicken anti-mouse IgG(H+L)

9-20222
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 chicken anti-rabbit IgG(H+L)

9-20223
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 chicken anti-rabbit IgG(H+L)

9-20224
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A chicken anti-goat IgG(H+L)

9-20225
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 chicken anti-goat IgG(H+L)

9-20226
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 chicken anti-goat IgG(H+L)

9-20227
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-human IgG(H+L), highly cross-adsorbed

9-20230
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20231
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20232
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20233
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20234
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20235
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-swine IgG(H+L)

9-20236
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF680 rabbit anti-guinea pig IgG(H+L)

9-20243
  • EUR 306.00
  • EUR 312.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF770 rabbit anti-guinea pig IgG(H+L)

9-20244
  • EUR 306.00
  • EUR 312.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20275
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 donkey anti-guinea pig IgG (H+L), highly cross-adsorbed

9-20276
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-human IgG(H+L), highly cross-adsorbed

9-20280
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20281
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20282
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20283
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20284
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20285
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-swine IgG(H+L)

9-20286
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20293
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20294
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20295
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20296
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20297
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Goat anti-mouse IgG (H+L), highly cross-adsorbed

9-20299
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Goat anti-rabbit IgG (H+L), highly cross-adsorbed

9-20300
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20301
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20302
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20303
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20304
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20305
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-mouse IgG(H+L)

9-20306
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20307
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20308
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-rabbit IgG(H+L)

9-20309
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20310
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-chicken IgY(H+L), highly cross-adsorbed

9-20311
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 rabbit anti-chicken IgY (IgG) (H+L)

9-20312
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20313
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20314
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 rabbit anti-goat IgG(H+L)

9-20315
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-guinea pig IgG (H+L), highly cross-adsorbed

9-20316
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-guinea pig IgG(H+L)

9-20317
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-human IgG(H+L), highly cross-adsorbed

9-20318
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-human IgG(H+L), highly cross-adsorbed

9-20319
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-rat IgG(H+L), highly cross-adsorbed

9-20320
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20321
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20322
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 rabbit anti-sheep IgG(H+L), highly cross-adsorbed

9-20323
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-swine IgG(H+L)

9-20324
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20328
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 Chicken Anti-Mouse IgG(H+L), 2 mg/mL

9-20331
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF350 Chicken Anti-Rabbit IgG(H+L), 2 mg/mL

9-20332
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF543 Chicken Anti-Goat IgG(H+L), 2 mg/mL

9-20333
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF543 Chicken Anti-Mouse IgG(H+L), 2 mg/mL

9-20334
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF543 Chicken Anti-Rabbit IgG(H+L), 2 mg/mL

9-20335
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF543 Rabbit Anit-Guinea Pig IgG(H+L), 2 mg/mL

9-20336
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF568 Chicken Anti-Goat IgG(H+L), 2 mg/mL

9-20337
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF568 Chicken Anti-Mouse IgG(H+L), 2 mg/mL

9-20338
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF568 Chicken Anti-Rabbit IgG(H+L), 2 mg/mL

9-20339
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF405M Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat), 2 mg/mL

9-20340
  • EUR 396.00
  • EUR 388.80
  • EUR 164.40
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF633 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat), 2 mg/mL

9-20341
  • EUR 396.00
  • EUR 388.80
  • EUR 164.40
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF647 Goat Anti-Human IgM (mu chain), 2mg/mL

9-20346
  • EUR 248.40
  • EUR 164.40
  • 250uL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF488A Goat Anti-Human IgM (mu chain), 2mg/mL

9-20347
  • EUR 248.40
  • EUR 164.40
  • 250uL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF594 Goat Anti-Human IgM (mu chain), 2mg/mL

9-20348
  • EUR 248.40
  • EUR 164.40
  • 250uL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF640R Goat Anti-Human IgM (mu chain), 2mg/mL

9-20349
  • EUR 248.40
  • EUR 164.40
  • 250uL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF350 Donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20350
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 Donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20351
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

In addition, miR-133b mimic promoted proliferation and migration, Notch1 and Jagged1 upregulated and downregulated Notch3 in VSMC ox-LDL-induced. Taken together, miR-133b worsen the US by activating Notch signaling pathway, which could serve as a potential target for the treatment of AS.

Anthony

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