Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

Background: Recently, Notch signaling pathway has gained attention as a potential therapeutic target for chemotherapeutic intervention. However, the efficacy of previously known inhibitors of Notch in colon cancer remains unclear. The purpose of this study was to determine the effect of andrographolide in aberrantly activated Notch signaling in SW-480 cells in vitro.


Methods: The potential cytostatic andrografolida on SW-480 cells was evaluated by 3- (4,5-dimethylthiazol-2-yl) -2, 5-diphenyl tetrazolium bromide (MTT) assay, assessment of morphology and colony formation test. FITC apoptosis activity was evaluated by Annexin V assay, 4 ‘, 6-diamidino-2-phenylindole (DAPI), Hoechst, Rhodamine 123 and Mito Tracker staining CMXRos. Scratching assay for assessment of potential migration. 7’-Dichlorodihydrofluorescein Diacetate (DCFH-DA) staining was used to evaluate Reactive Oxygen Species (ROS) generation. mRNA relative expression of Bax, Bcl-2, NOTCH 1 and jagged 1 was estimated by real-time quantitative reverse transcription PCR (qRT-PCR). cell cycle phase distribution was evaluated Annexin V-FITC / PI staining.


Results: MTT assay showed a dose and time dependent cytoxicity of andrographolide on SW-480 cells. It also inhibits migratory and colony forming potential of SW-480 cells. In addition, andrografolida also showed impaired mitochondrial membrane potential and induced apoptosis through nuclear condensation. Flow cytometric evaluation showed improved early and late andrographolide cells induced apoptosis and upregulation of proapoptotic (Bax and Bad) and downregulation of Bcl-2 antiapoptotic in SW-480 treated cells. Andrographolide plus intracellular ROS and induced G0 / G1 phase cell cycle arrest in SW480 colon cancer cells. Furthermore, andrografolida suppress Notch signaling by reducing the expression of NOTCH 1 and jagged one.
Conclusions: Our findings indicate that the andrographolide constraints SW-480 cell growth through inhibition of the Notch signaling pathway.

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway
Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

MicroRNA-133b exacerbate atherosclerosis by activating the Notch signaling pathway1

The purpose of this study was to determine the effect of miR-133b in atherosclerosis (AS). A rat model of AS (AS Group) was established, and serum levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein (LDL) cholesterol were detected. The thoracic aorta tissue was subjected to hematoxylin and eosin staining for pathological examination. Mice were intravenously injected with microRNA (mir) -133b mimic (group miR-133b mimic + US) and miR-133b mimic negative control (miR-133b group NC + US).

Normal mice given the name of Sham group. reconstruction parameters of vascular, inflammatory factors Ratio Collagen / Vascular Area (CA / CVA) and serum of mice in each group were detected. MRNA expression was measured by quantitative reverse transcription-PCR and protein expression was determined by western blot analysis. An in vitro model of the US induced in vascular smooth muscle cells (VSMC) using oxidized (ox) -LDL. CCK-8 and wound healing tests used to detect cell proliferation and migration.

Compared with Sham group, the rats of the US group, AS + miR-133b mimic NC group and the group AS + miR-133b have a higher intima thickness (IT), tumor necrosis factor (TNF) -α and monocytes kemoatraktan protein (MCP) -1 level, as well as increased expression of Notch1 and Jagged1; and they have a lower medial thickness (MT), the ratio CA / CVA and Notch3 expression (all P <0.05).

Cancer MicroRNA qPCR Array

RA610A-1 10 profiles
EUR 1406.4

LncRNA Profiler qPCR Array Kit (cDNA synthesis kit and qPCR array) 20 profiles

RA900A-1 20 profiles
EUR 1020

LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles

RA910A-1 20 profiles
EUR 1329.6

Mouse p53 Signaling Primer Library

MTPS-I 1 set
EUR 540

Mouse WNT Signaling Primer Library

MWNT-I 1 set
EUR 657.6

Mouse Ras Signaling Primer Library

MRAS-I 1 set
EUR 657.6

Mouse BMP Signaling Primer Library

MBMP-I 1 set
EUR 657.6

Mouse CREB Signaling Primer Library

MCREB-I 1 set
EUR 657.6

Mouse Gdnf Signaling Primer Library

MGDNF-I 1 set
EUR 657.6

Mouse Bdnf Signaling Primer Library

MBDNF-I 1 set
EUR 657.6

Mouse EGFR Signaling Primer Library

MEGFR-I 1 set
EUR 657.6

Mouse Hippo Signaling Primer Library

MHPO-I 1 set
EUR 657.6

Mouse Hypoxia Signaling Primer Library

MHYP-I 1 set
EUR 657.6

Mouse Integrin Signaling Primer Library

MINT-I 1 set
EUR 891.6

Mouse Estrogen Receptor Signaling Library

MESR-I 1 set
EUR 774

Mouse TGF Beta Signaling Primer Library

MTGFB-I 1 set
EUR 657.6

Mouse Jak/Stat Signaling Primer Library

MJAK-I 1 set
EUR 774

Mouse DNA Damage Signaling Primer Library

MDDS-I 1 set
EUR 657.6

Mouse MAP Kinase Signaling Primer Library

MMAP-I 1 set
EUR 657.6

Mouse PI3K-AKT Signaling Primer Library

MAKT-I 1 set
EUR 657.6

Mouse Suppressors Of Cytokine Signaling 1

E01A25244 96T
EUR 700
Description: ELISA

Mouse Fatty Liver Signaling Primer Library

MFTL-I 1 set
EUR 657.6

Mouse Neurotransmitter Signaling Primer Library

MNTS-I 1 set
EUR 657.6

Mouse Agouti Signaling Protein (ASIP) ELISA Kit

abx388547-96tests 96 tests
EUR 1093.2

Mouse Agouti signaling protein(ASIP) ELISA kit

E01A18608 96T
EUR 700
Description: ELISA

Mouse Agouti signaling protein(ASIP) ELISA kit

E03A1721-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Agouti signaling protein(ASIP) ELISA kit

E03A1721-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Agouti signaling protein(ASIP) ELISA kit

E03A1721-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Agouti signaling protein(ASIP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Agouti- signaling protein, Asip ELISA KIT

ELI-49356m 96 Tests
EUR 1038

Mouse Suppressor of cytokine signaling 1 (Socs1)

1-CSB-EP022388MO
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Description: Recombinant Mouse Suppressor of cytokine signaling 1(Socs1) expressed in E.coli

Agouti Signaling Protein (ASP) (92-131) amide (Mouse)

003-69 100 μg
EUR 316.44

Mouse T-Cell Receptor Signaling Primer Library

MTCR-I 1 set
EUR 657.6

Mouse Toll-like Receptor Signaling Primer Library

newitem 1 set
EUR 657.6

Mouse Suppressors Of Cytokine Signaling 3 ELISA kit

E01A25243 96T
EUR 700
Description: ELISA

Mouse Suppressors Of Cytokine Signaling 3 ELISA kit

E03S0137-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Suppressors Of Cytokine Signaling 3 ELISA kit

E03S0137-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Suppressors Of Cytokine Signaling 3 ELISA kit

E03S0137-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Suppressors Of Cytokine Signaling 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Suppressors Of Cytokine Signaling 1 ELISA kit

E03S0138-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Suppressors Of Cytokine Signaling 1 ELISA kit

E03S0138-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Suppressors Of Cytokine Signaling 1 ELISA kit

E03S0138-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Suppressors Of Cytokine Signaling 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Suppressors Of Cytokine Signaling 1 ELISA Kit

IMSSOCS1KT each
EUR 752
Description: Mouse Suppressors Of Cytokine Signaling 1 ELISA Kit

Mouse Suppressors Of Cytokine Signaling 2 ELISA Kit

IMSSOCS2KT each
EUR 752
Description: Mouse Suppressors Of Cytokine Signaling 2 ELISA Kit

Mouse Suppressors Of Cytokine Signaling 3 ELISA Kit

IMSSOCS3KT each
EUR 718
Description: Mouse Suppressors Of Cytokine Signaling 3 ELISA Kit

Mouse Regulator Of G Protein Signaling 4 ELISA kit

E01A24946 96T
EUR 700
Description: ELISA

Mouse Regulator Of G Protein Signaling 1 ELISA kit

E01A25161 96T
EUR 700
Description: ELISA

Mouse Regulator Of G Protein Signaling 4 ELISA kit

E03R0039-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Regulator Of G Protein Signaling 4 ELISA kit

E03R0039-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Regulator Of G Protein Signaling 4 ELISA kit

E03R0039-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Regulator Of G Protein Signaling 4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Regulator Of G Protein Signaling 6 ELISA Kit

IMSRGS6KT each
EUR 752
Description: Mouse Regulator Of G Protein Signaling 6 ELISA Kit

Mouse Regulator Of G Protein Signaling 9 (RGS9) Protein

20-abx650445
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Mouse Regulator Of G Protein Signaling 3 (RGS3) Protein

20-abx650448
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Mouse G Protein Signaling Modulator 1 (GPSM1) ELISA Kit

abx257546-96tests 96 tests
EUR 764.4

Mouse Regulator Of G Protein Signaling 5 (RGS5) Protein

20-abx165933
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Mouse G- protein- signaling modulator 2, Gpsm2 ELISA KIT

ELI-31711m 96 Tests
EUR 1038

Mouse G- protein- signaling modulator 3, Gpsm3 ELISA KIT

ELI-42858m 96 Tests
EUR 1038

Mouse G- protein- signaling modulator 1, Gpsm1 ELISA KIT

ELI-27948m 96 Tests
EUR 1038

Mouse Regulator Of G Protein Signaling 5 (RGS5) Protein

abx165933-100g 100 µg
EUR 575

Mouse Regulator Of G Protein Signaling 5 (RGS5) Protein

abx165933-10g 10 µg
EUR 225

Mouse Regulator Of G Protein Signaling 5 (RGS5) Protein

abx165933-50g 50 µg
EUR 400

Mouse G Protein Signaling Modulator 1 (GPSM1) ELISA Kit

abx257546-05mg 0.5 mg Ask for price

Mouse G Protein Signaling Modulator 1 (GPSM1) ELISA Kit

abx257546-100g 100 µg
EUR 687.5

Mouse G Protein Signaling Modulator 1 (GPSM1) ELISA Kit

abx257546-1mg 1 mg Ask for price

Mouse Regulator Of G Protein Signaling 9 (RGS9) Protein

abx650445-100g 100 µg
EUR 525

Mouse Regulator Of G Protein Signaling 9 (RGS9) Protein

abx650445-10g 10 µg
EUR 212.5

Mouse Regulator Of G Protein Signaling 9 (RGS9) Protein

abx650445-50g 50 µg
EUR 362.5

Mouse Regulator Of G Protein Signaling 3 (RGS3) Protein

abx650448-100g 100 µg
EUR 412.5

Mouse Regulator Of G Protein Signaling 3 (RGS3) Protein

abx650448-200g 200 µg
EUR 600

Mouse Regulator Of G Protein Signaling 3 (RGS3) Protein

abx650448-50g 50 µg
EUR 225

Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) Protein

20-abx069208
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Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) Protein

abx069208-1g 1 g
EUR 187.5

Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) Protein

abx069208-5g 5 g
EUR 325

Mouse Regulator Of G Protein Signaling 10 (RGS10) Protein

20-abx650446
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Mouse SRC kinase signaling inhibitor 1 (SRCIN1) ELISA Kit

abx390644-96tests 96 tests
EUR 1093.2

Mouse SRC kinase signaling inhibitor 1, Srcin1 ELISA KIT

ELI-18126m 96 Tests
EUR 1038

Mouse SRC kinase signaling inhibitor 1 (SRCIN1) ELISA Kit

abx390644-500g 500 µg
EUR 687.5

Mouse Regulator Of G Protein Signaling 10 (RGS10) Protein

abx650446-5mg 5 mg
EUR 350

Mouse Regulator Of G Protein Signaling 5 (RGS5) CLIA Kit

20-abx494359
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Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) CLIA Kit

abx197732-96tests 96 tests
EUR 990

Mouse Suppressor of cytokine signaling 2 (SOCS2) ELISA Kit

abx254950-96tests 96 tests
EUR 801.6

Mouse Suppressor of Cytokine Signaling 1 (SOCS1) ELISA Kit

abx254952-96tests 96 tests
EUR 801.6

Mouse Suppressor of cytokine signaling 3 (SOCS3) ELISA Kit

abx571460-96tests 96 tests
EUR 801.6

Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) CLIA Kit

20-abx492986
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  • 10 × 96 tests
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Mouse Socs1/ Suppressor of cytokine signaling 1 ELISA Kit

E1388Mo 1 Kit
EUR 543
Description: Cish1,Ssi1,JAK-binding protein,STAT-induced STAT inhibitor 1,JAB,SSI-1

Mouse Socs2/ Suppressor of cytokine signaling 2 ELISA Kit

E1389Mo 1 Kit
EUR 543
Description: Cis2,Cish2,Cytokine-inducible SH2 protein 2,CIS-2

Mouse Suppressor of cytokine signaling 7, Socs7 ELISA KIT

ELI-35978m 96 Tests
EUR 1038

Mouse Suppressor of cytokine signaling 4, Socs4 ELISA KIT

ELI-18244m 96 Tests
EUR 1038

Mouse Suppressor of cytokine signaling 2, Socs2 ELISA KIT

ELI-04605m 96 Tests
EUR 1038

Mouse Suppressor of cytokine signaling 1, Socs1 ELISA KIT

ELI-04612m 96 Tests
EUR 1038

Mouse Suppressor of cytokine signaling 3, Socs3 ELISA KIT

ELI-05495m 96 Tests
EUR 1038

Mouse Suppressor of cytokine signaling 5, Socs5 ELISA KIT

ELI-52274m 96 Tests
EUR 1038

Mouse Suppressor of cytokine signaling 6, Socs6 ELISA KIT

ELI-53004m 96 Tests
EUR 1038

Mouse SOCS2( Suppressor of cytokine signaling 2) ELISA Kit

EM0599 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 46.9pg/ml

Mouse SOCS1( Suppressor of cytokine signaling 1) ELISA Kit

EM0601 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Mouse Suppressor of cytokine signaling 2 (SOCS2) ELISA Kit

RK08095 96T
EUR 280

Mouse Suppressors of Cytokine Signaling 3 (SOCS3) CLIA Kit

abx197732-100l 100 µl Ask for price

Mouse Suppressors of Cytokine Signaling 3 (SOCS3) CLIA Kit

abx197732-50l 50 µl
EUR 618.75

Mouse Suppressor Of Cytokine Signaling 4 (SOCS4) ELISA Kit

abx546661-96tests 96 tests
EUR 687.5

Mouse Suppressor of Cytokine Signaling 5 (SOCS5) ELISA Kit

abx546664-96tests 96 tests
EUR 687.5

Mouse Suppressor of Cytokine Signaling 6 (SOCS6) ELISA Kit

abx546666-96tests 96 tests
EUR 618.75

Mouse Suppressor of cytokine signaling 7 (SOCS7) ELISA Kit

abx546668-96tests 96 tests
EUR 687.5

Mouse SOCS3 -Suppressors Of Cytokine Signaling 3- CLIA Kit

E-CL-M0622-24Tests 24 Tests
EUR 180
Description: Sandwich

Mouse SOCS3 -Suppressors Of Cytokine Signaling 3- CLIA Kit

E-CL-M0622-48Tests 48 Tests
EUR 546
Description: Sandwich

Mouse SOCS3 -Suppressors Of Cytokine Signaling 3- CLIA Kit

E-CL-M0622-96Tests 96 Tests
EUR 682
Description: Sandwich

Mouse SOCS3 -Suppressors Of Cytokine Signaling 3- CLIA Kit

E-CL-M0622-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Mouse SOCS3 -Suppressors Of Cytokine Signaling 3- CLIA Kit

E-CL-M0622-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Mouse Socs3 / Suppressor of cytokine signaling 3 ELISA Kit

E1684m 96T
EUR 776

Mouse Socs6 / Suppressor of cytokine signaling 6 ELISA Kit

E13126m 96T
EUR 776

Mouse Socs2 / Suppressor of cytokine signaling 2 ELISA Kit

E1415m 96T
EUR 776

Mouse Socs1 / Suppressor of cytokine signaling 1 ELISA Kit

E1416m 96T
EUR 776

Mouse Regulator Of G Protein Signaling 7 (RGS7) ELISA Kit

20-abx585177
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  • 10 × 96 tests
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  • 96 tests

Mouse Regulator Of G Protein Signaling 9 (RGS9) ELISA Kit

20-abx585181
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  • 10 × 96 tests
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  • 96 tests

Mouse Regulator Of G Protein Signaling 5 (RGS5) ELISA Kit

20-abx154618
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  • 10 × 96 tests
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  • 96 tests

Mouse Regulator Of G Protein Signaling 4 (RGS4) ELISA Kit

abx353021-96tests 96 tests
EUR 943.2

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

DLR-RGS6-Mu 96T
EUR 475
Description: tissue homogenates or other biological fluids.

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

DLR-RGS6-Mu-48T 48T
EUR 632.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Regulator Of G Protein Signaling 6 (RGS6) in samples from tissue homogenates or other biological fluids.

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

DLR-RGS6-Mu-96T 96T
EUR 825.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Regulator Of G Protein Signaling 6 (RGS6) in samples from tissue homogenates or other biological fluids.

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

DL-RGS6-Mu 96T
EUR 453
Description: tissue homogenates or other biological fluids.

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

EK17545 96Т
EUR 768

Mouse Regulator Of G Protein Signaling 5 (RGS5) ELISA Kit

EKN48168-48T 48T
EUR 389.62

Mouse Regulator Of G Protein Signaling 5 (RGS5) ELISA Kit

EKN48168-5x96T 5x96T
EUR 2643.85

Mouse Regulator Of G Protein Signaling 5 (RGS5) ELISA Kit

EKN48168-96T 96T
EUR 556.6

Mouse Regulator Of G Protein Signaling 7 (RGS7) ELISA Kit

EKU11393-48T 48T
EUR 571.55

Mouse Regulator Of G Protein Signaling 7 (RGS7) ELISA Kit

EKU11393-5x96T 5x96T
EUR 3878.38

Mouse Regulator Of G Protein Signaling 7 (RGS7) ELISA Kit

EKU11393-96T 96T
EUR 816.5

Mouse Regulator Of G Protein Signaling 9 (RGS9) ELISA Kit

EKU11396-48T 48T
EUR 571.55

Mouse Regulator Of G Protein Signaling 9 (RGS9) ELISA Kit

EKU11396-5x96T 5x96T
EUR 3878.38

Mouse Regulator Of G Protein Signaling 9 (RGS9) ELISA Kit

EKU11396-96T 96T
EUR 816.5

Mouse Regulator of G- protein signaling 7, Rgs7 ELISA KIT

ELI-30318m 96 Tests
EUR 1038

Mouse Regulator of G- protein signaling 1, Rgs1 ELISA KIT

ELI-35559m 96 Tests
EUR 1038

Mouse Regulator of G- protein signaling 8, Rgs8 ELISA KIT

ELI-21894m 96 Tests
EUR 1038

Mouse Regulator of G- protein signaling 4, Rgs4 ELISA KIT

ELI-18003m 96 Tests
EUR 1038

Mouse Regulator of G- protein signaling 5, Rgs5 ELISA KIT

ELI-19255m 96 Tests
EUR 1038

Mouse Regulator of G- protein signaling 6, Rgs6 ELISA KIT

ELI-19256m 96 Tests
EUR 1038

Mouse Regulator of G- protein signaling 9, Rgs9 ELISA KIT

ELI-06882m 96 Tests
EUR 1038

Mouse Regulator Of G Protein Signaling 7 (RGS7) ELISA Kit

EKN52504-48T 48T
EUR 355.6

Mouse Regulator Of G Protein Signaling 7 (RGS7) ELISA Kit

EKN52504-5x96T 5x96T
EUR 2413

Mouse Regulator Of G Protein Signaling 7 (RGS7) ELISA Kit

EKN52504-96T 96T
EUR 508

Mouse Regulator Of G Protein Signaling 9 (RGS9) ELISA Kit

EKN52507-48T 48T
EUR 355.6

Mouse Regulator Of G Protein Signaling 9 (RGS9) ELISA Kit

EKN52507-5x96T 5x96T
EUR 2413

Mouse Regulator Of G Protein Signaling 9 (RGS9) ELISA Kit

EKN52507-96T 96T
EUR 508

Mouse RGS5(Regulator Of G Protein Signaling 5) ELISA Kit

ELK7289-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse RGS5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse RGS5. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse RGS5, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse RGS5 in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse RGS5(Regulator Of G Protein Signaling 5) ELISA Kit

ELK7289-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse RGS5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse RGS5. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse RGS5, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse RGS5 in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse Regulator Of G Protein Signaling 5 (RGS5) ELISA Kit

EKU07057-48T 48T
EUR 571.55

Mouse Regulator Of G Protein Signaling 5 (RGS5) ELISA Kit

EKU07057-5x96T 5x96T
EUR 3878.38

Mouse Regulator Of G Protein Signaling 5 (RGS5) ELISA Kit

EKU07057-96T 96T
EUR 816.5

Mouse Regulator of G- protein signaling 2, Rgs2 ELISA KIT

ELI-52654m 96 Tests
EUR 1038

Mouse Regulator Of G Protein Signaling 6(RGS6)ELISA Kit

QY-E21314 96T
EUR 433.2

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

RDR-RGS6-Mu-48T 48T
EUR 487.52
Description: tissue homogenates and other biological fluids.

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

RDR-RGS6-Mu-48Tests 48 Tests
EUR 668.4

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

RDR-RGS6-Mu-96T 96T
EUR 696.47
Description: tissue homogenates and other biological fluids.

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

RDR-RGS6-Mu-96Tests 96 Tests
EUR 928.8

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

RD-RGS6-Mu-48T 48T
EUR 464.3
Description: tissue homogenates and other biological fluids.

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

RD-RGS6-Mu-48Tests 48 Tests
EUR 639.6

Mouse Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit

RD-RGS6-Mu-96T 96T
EUR 663.3
Description: tissue homogenates and other biological fluids.

In addition, miR-133b mimic promoted proliferation and migration, Notch1 and Jagged1 upregulated and downregulated Notch3 in VSMC ox-LDL-induced. Taken together, miR-133b worsen the US by activating Notch signaling pathway, which could serve as a potential target for the treatment of AS.

Anthony

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Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma

TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma

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