Notch signaling pathway

elegans lin-12, informed by the first oncogenic mutation affecting a human Notch gene

SPON2 Is Upregulated through Notch Signaling Pathway and Promotes Tumor Progression in Gastric Cancer

SPON2 Is Upregulated through Notch Signaling Pathway and Promotes Tumor Progression in Gastric Cancer

Spondin-2 (SPON2) involved in cancer development and metastasis of many tumors; However, the role and the underlying mechanisms in gastric cancer is still unclear. In this study, we examined the role SPON2 and associated signaling pathway in gastric cancer progression and metastasis. SPON2 expression level was found to be regulated in gastric cancer cell lines and tissues of patients compared to gastric epithelial cells of normal and normal controls.

Furthermore, SPON2 silencing was observed to reduce cell proliferation and motility and reduce tumor growth in xenograft mice. Conversely, excess SPON2 found to increase cell proliferation and motility. Next, we focus on regulatory mechanisms SPON2 in gastric cancer. cDNA microarray and in vitro studies suggest that Notch signaling was significantly correlated with the expression SPON2.

Therefore, we confirm how Notch signaling pathway regulates the expression of Notch-related SPON2 using signaling interactions of transcription factors and reporter gene assay. In addition, activation of Notch signaling is observed to increase cell proliferation, migration, and invasion through SPON2 expression. Our study suggests that Notch signaling-mediated upregulation SPON2 associated with aggressive development of gastric cancer. In conclusion, we recommend SPON2 regulated by Notch signaling as a potential target gene to inhibit the development of gastric cancer.

SPON2 Is Upregulated through Notch Signaling Pathway and Promotes Tumor Progression in Gastric Cancer
SPON2 Is Upregulated through Notch Signaling Pathway and Promotes Tumor Progression in Gastric Cancer

PNO1, which negatively regulated by miR-340-5p, promoting the development of adenocarcinoma of the lung through the Notch signaling pathway

Many studies have shown that hyperactivation of ribosome biogenesis plays an important role in the initiation and progression of cancer. As the ribosome assembly factor, PNO1 play an important role in ribosome biogenesis. However, little is known about the expression and function in human tumors PNO1. In our study, we aimed to explore the functional role and molecular mechanisms that underlie PNO1 in human lung adenocarcinoma (LUAD). Both bioinformatics databases and tumor tissues showed that expression in tissues LUAD PNO1 higher than in the adjacent tissue and predicted poor survival in patients LUAD. In vitro and in vivo tests showed that downregulation of the expression of PNO1 suppressed cell proliferation and invasion LUAD. Further research found that miR-340-5p PNO1 depressed expression via direct binding to the 3 ‘translated region (UTR) of PNO1.

PNO1 expression negatively correlated with miR-340-5p LUAD expression in cells and tissue samples. Moreover, upregulation or downregulation of the expression of miR-340-5p reversed the inhibitory effects and excessive PNO1, respectively. Meanwhile, downregulation of Notch signaling pathway inhibits PNO1 modulated epithelial mesenchymal transition (EMT). These results indicate that PNO1, negatively regulated by miR-340-5p, plays an important role in the development of LUAD through the Notch signaling pathway. The miR-340-5p / PNO1 / Notch axis may be a potential target for the treatment of the individual and the right of patients LUAD in the future.
Forty Kunming mice were randomly divided into normal group (n = 10) and model group (n = 30).

Nylon Array

MVSNGA120 20 Slides
EUR 363

Human Drug Detoxication I

HDTX-I 1 set
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Human Drug Detoxication II

HDTX-II 1 set
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Green qPCR SuperMix

20-abx098031
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Universal qPCR Mixture

QPCR1000-UNIV 4X1.25ml
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PKG drug G1

HY-112197 10mM/1mL
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Thiamphenicol Drug [HRP]

DAGA-031H 1mg
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DAGA-038B 1mg
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Ibrutinib drug-Human IgG Conjugate

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Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)

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Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)

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Green qPCR SuperMix UDG

20-abx098032
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Tip Green qPCR SuperMix

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Neural Lineage qPCR Profiler

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HDTP-I 1 set
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HIV-P24 antigen array kit

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Procalcitonin (PCT) Antigen array kit

VArk-Lsx004 1 mg
EUR 811
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NT-pro BNP array kit

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EUR 1489
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Streptavidin Blue Array Particle Kit

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UV Carboxyl Particle Array Kit

UVCPAK--5042-14K 14X1 mL
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Exo-Check Exosome Antibody Array

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BrightGreen 5X qPCR MasterMix-iCycler

MasterMix-5C 4 x 1.0 ml for 1000 reactions (20 ul)
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BrightGreen 2X qPCR MasterMix-ROX

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AceQ qPCR Probe Master Mix

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HotTaq Probe qPCR Mix (ROX)

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Methylamp MS-qPCR Fast Kit

P-1028 200 Reactions
EUR 496.6
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SYBR Green qPCR Master Mix

HY-K0501 5 mL (500 rxns)
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RT Master Mix for qPCR

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HDAC Inhibitor Drug Screening Kit

55R-1376 100 assays
EUR 825
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55R-1448 100 assays
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55R-1538 100 assays
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MMP1 Inhibitor Drug Screening Kit

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DEIANJ33 96T
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DiscoveryProbe? FDA-approved Drug Library

L1021-.1 100 uL/well(10 mM solution)
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DiscoveryProbe? FDA-approved Drug Library

L1021-.25 250 uL/well(10 mM solution)
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DiscoveryProbe? FDA-approved Drug Library

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DiscoveryProbe? FDA-approved Drug Library

L1021-5 5 mg/well
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FDA Standard Frozen Tissue Array - Human Adult Normal

T6234701-1 2 slides
EUR 1120
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FDA Standard Frozen Tissue Array - Human Adult Normal

T6234701-2 4 slides
EUR 2034
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Multiple Species Frozen Tissue Array - Brain

T6134035-1 1 slide
EUR 220
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Species Frozen Tissue Array - Brain

T6134035-5 5 slides
EUR 670
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Species Frozen Tissue Array - Liver

T6134149-1 1 slide
EUR 220
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Species Frozen Tissue Array - Liver

T6134149-5 5 slides
EUR 670
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Species Paraffin Tissue Array - Brain

T8134035-2 2 slides
EUR 249
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Species Paraffin Tissue Array - Brain

T8134035-5 5 slides
EUR 450
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Species Paraffin Tissue Array - Liver

T8134149-2 2 slides
EUR 249
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Species Paraffin Tissue Array - Liver

T8134149-5 5 slides
EUR 450
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Carboxyl Blue Particle Array Chemistry Development

CFP-5067-2 2 mL
EUR 218
Description: Gentaur distributes carboxyl, functionalized surface groups used for covalent coupling.If you need more technical information please contact our dedicated team via live chat, phone or email.

Carboxyl Magnetic Blue Particle Array Kit

CMPAK-4068-6K 6x1 mL
EUR 310
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Carboxyl Magnetic Blue Particle Array Kit

CMPAK-5068--6K 6x1 mL
EUR 310
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Tuberculosis (TB)  Interferon-γ array kit

VArk-Lsx003 unit Ask for price
Description: Used in Interferon Gamma Release Assay (IGRA) to detect Tuberculosis (TB)

Glycocholic Acid (CG) antibody array kit

VArk-Lsx005 1 mg
EUR 1875
Description: Used for detection of Glycocholic Acid

Opti-Seal qPCR and Storage Films

G495 100 Films/Box
EUR 202

Opti-Seal qPCR 384 Well Plate

G935 10 Plates/Box
EUR 89

Opti-Seal qPCR 384 Well Plate

G936 100 Plates/Case
EUR 428

Coronavirus Rapid RT-qPCR Detection Kit

K1461-100 100 Rxns
EUR 551

Adeno-Associated Virus qPCR Quantification Kit

K1473-100 100 Rxns
EUR 348

2x SYBR Green qPCR Master Mix

B21202 5 mL
EUR 224
Description: Our 2x SYBR Green qPCR master mix performs toe to toe in all qPCR assays with the most well known brands on the market but surpases them significantly in cost-efficiency.

2x SYBR Green qPCR Master Mix

B21203 25 mL
EUR 856
Description: Our 2x SYBR Green qPCR master mix performs toe to toe in all qPCR assays with the most well known brands on the market but surpases them significantly in cost-efficiency.

BrightGreen 5X qPCR MasterMix-Low ROX

MasterMix-5L 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213

TaqProbe 5X qPCR MasterMix-Low ROX

MasterMix-5PL 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213

TaqProbe 5X qPCR MasterMix-No Dye

MasterMix-5PS 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213

BrightGreen 5X qPCR MasterMix-No Dye

MasterMix-5S 4 x 1.0 ml for 1000 reactions (20 ul)
EUR 213

BrightGreen Express 2X qPCR MasterMix-iCycler

MasterMix-EC 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

BrightGreen Express 2X qPCR MasterMix-ROX

MasterMix-ER 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

KiloGreen 2X qPCR MasterMix-Low ROX

MasterMix-KL 4 x 1.25 ml - 500 reactions (20 ul)
EUR 140

KiloGreen 2X qPCR MasterMix-No Dye

MasterMix-KS 4 x 1.25 ml - 500 reactions (20 ul)
EUR 140

BrightGreen 2X qPCR MasterMix-Low ROX

MasterMix-LR 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

BrightGreen 2X qPCR MasterMix-Low ROX

MasterMix-LR-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 376

BrightGreen miRNA qPCR MasterMix-Low ROX

MasterMix-mL 4 x 1.25 ml for 500 reactions
EUR 151

BrightGreen miRNA qPCR MasterMix-No Dye

MasterMix-mS 4 x 1.25 ml for 500 reactions
EUR 151

TaqProbe 2X qPCR MasterMix-Low ROX

MasterMix-PL 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

TaqProbe 2X qPCR MasterMix-No Dye

MasterMix-PS 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

BrightGreen 2X qPCR MasterMix-No Dye

MasterMix-S 4 x 1.25 ml for 500 reactions (20 ul)
EUR 140

BrightGreen 2X qPCR MasterMix-No Dye

MasterMix-S-XL 16 x 1.25 ml for 2000 reactions (20 ul)
EUR 376

Pro QPCR SuperMix Kit - ROX premixed

K5056200 200 reactions
EUR 188
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Pro QPCR SuperMix Kit - ROX premixed

K5056400 400 reactions
EUR 299
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

AceQ Universal SYBR qPCR Master Mix

Q511-02 500 rxn (20 μl/rxn)
EUR 221

AceQ Universal SYBR qPCR Master Mix

Q511-03 2500 rxn (20 μl/rxn)
EUR 646

ChamQ Universal SYBR qPCR Master Mix

Q711-02 500 rxn (20 μl/rxn)
EUR 221

ChamQ Universal SYBR qPCR Master Mix

Q711-03 2500 rxn (20 μl/rxn)
EUR 646

igScript RT-qPCR Kit - 50 Reactions

4513 1/EA
EUR 248

Universal miRNA qPCR Primer (10 µM)

abx298006-200ul 200 ul
EUR 189

Top Green qPCR SuperMix (+Dye II)

20-abx098890
  • EUR 829.00
  • EUR 217.00
  • EUR 1135.00
  • EUR 411.00
  • 15 ml
  • 1 ml
  • 25 ml
  • 5 ml

Tip Green qPCR SuperMix (+Dye II)

20-abx098891
  • EUR 968.00
  • EUR 230.00
  • EUR 1330.00
  • EUR 467.00
  • 15 ml
  • 1 ml
  • 25 ml
  • 5 ml

Model of ulcerative colitis induced by free drinking of 2% dextran sulfate sodium (DSS). After 15 days, rats were divided into model group, 6-gingerenol group and positive control group with 10 rats in each group. normal group and model group were treated with normal saline, 6-gingerenol group treated with 6-shogaol 100 mg / (kg · d), the positive control group treated with sulfasalazine 100 mg / (kg · d) for 20 days. Intestinal histopathological changes were observed, and the expression of Hes-1 and Mathematics-1protein in colonic epithelial cells was detected by double immunofluorescence labeling method.

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